Editing Epigenetics (section)

==== ''FADS1'' locus ====
Fatty acid desaturase 1 (FADS1) is a key enzyme in the metabolism of fatty acids.<ref>{{cite journal | vauthors = He Z, Zhang R, Jiang F, Zhang H, Zhao A, Xu B, Jin L, Wang T, Jia W, Jia W, Hu C | title = FADS1-FADS2 genetic polymorphisms are associated with fatty acid metabolism through changes in DNA methylation and gene expression | journal = Clinical Epigenetics | volume = 10 | issue = 1 | pages = 113 | date = August 2018 | pmid = 30157936 | pmc = 6114248 | doi = 10.1186/s13148-018-0545-5 | doi-access = free }}</ref> Moreover, rs174548 in the ''FADS1'' gene shows increased correlation with DNA methylation in people with high abundance of CD8+ T cells.<ref name="Hawe_2022" /> SNP rs174548 is strongly associated with concentrations of arachidonic acid and other metabolites in fatty acid metabolism,<ref>{{cite journal | vauthors = Guan W, Steffen BT, Lemaitre RN, Wu JH, Tanaka T, Manichaikul A, Foy M, Rich SS, Wang L, Nettleton JA, Tang W, Gu X, Bandinelli S, King IB, McKnight B, Psaty BM, Siscovick D, Djousse L, Chen YI, Ferrucci L, Fornage M, Mozafarrian D, Tsai MY, Steffen LM | title = Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium | journal = Circulation: Cardiovascular Genetics | volume = 7 | issue = 3 | pages = 321–331 | date = June 2014 | pmid = 24823311 | doi = 10.1161/circgenetics.113.000208 | pmc = 4123862 }}</ref><ref name="pmid24816252">{{cite journal | vauthors = Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J, Arnold M, Erte I, Forgetta V, Yang TP, Walter K, Menni C, Chen L, Vasquez L, Valdes AM, Hyde CL, Wang V, Ziemek D, Roberts P, Xi L, Grundberg E, Waldenberger M, Richards JB, Mohney RP, Milburn MV, John SL, Trimmer J, Theis FJ, Overington JP, Suhre K, Brosnan MJ, Gieger C, Kastenmüller G, Spector TD, Soranzo N | title = An atlas of genetic influences on human blood metabolites | journal = Nature Genetics | volume = 46 | issue = 6 | pages = 543–550 | date = June 2014 | pmid = 24816252 | pmc = 4064254 | doi = 10.1038/ng.2982 }}</ref> blood eosinophil counts.<ref>{{Cite journal | vauthors = Astle WJ, ((UK Blood Trait GWAS Team)), ((Cambridge BLUEPRINT epigenome)) |date=2016-12-02 |title=A GWAS of 170,000 Individuals Identifies Thousands of Alleles Perturbing Blood Cell Traits, Many of Which Are in Super Enhancers Setting Cell Identity |journal=Blood |volume=128 |issue=22 |pages=2652 |doi=10.1182/blood.v128.22.2652.2652 |issn=0006-4971}}</ref> and inflammatory diseases such as asthma.<ref>{{cite journal | vauthors = Kamat MA, Blackshaw JA, Young R, Surendran P, Burgess S, Danesh J, Butterworth AS, Staley JR | title = PhenoScanner V2: an expanded tool for searching human genotype-phenotype associations | journal = Bioinformatics | volume = 35 | issue = 22 | pages = 4851–4853 | date = November 2019 | pmid = 31233103 | doi = 10.1093/bioinformatics/btz469 | pmc = 6853652 }}</ref> Interaction results indicated a correlation between rs174548 and asthma, providing new insights about fatty acid metabolism in CD8+ T cells with immune phenotypes.<ref name="Hawe_2022" />