Editing Epigenetics (section)

==== ''NFKBIE'' locus ====
SNP rs730775 is located in the first intron of ''NFKBIE'' and is a ''cis'' eQTL for ''NFKBIE'' in whole blood.<ref name="Hawe_2022" /> Nuclear factor (NF)-κB inhibitor ε (NFKBIE) directly inhibits NF-κB1 activity and is significantly co-expressed with NF-κB1, also, it is associated with rheumatoid arthritis.<ref>{{cite journal | vauthors = Okada Y | title = From the era of genome analysis to the era of genomic drug discovery: a pioneering example of rheumatoid arthritis | journal = Clinical Genetics | volume = 86 | issue = 5 | pages = 432–440 | date = November 2014 | pmid = 25060537 | doi = 10.1111/cge.12465 | s2cid = 8499325 }}</ref> Colocalization analysis supports that variants for the majority of the CpG sites in SNP rs730775 cause genetic variation at the ''NFKBIE'' locus which is suggestible linked to rheumatoid arthritis through ''trans'' acting regulation of DNA methylation by NF-κB.<ref name="Hawe_2022" />