Editing Epigenetics (section)

==== ''UBASH3B'' locus ====
''UBASH3B'' encodes a protein with tyrosine phosphatase activity, which has been previously linked to advanced neoplasia.<ref>{{cite journal | vauthors = Lee ST, Feng M, Wei Y, Li Z, Qiao Y, Guan P, Jiang X, Wong CH, Huynh K, Wang J, Li J, Karuturi KM, Tan EY, Hoon DS, Kang Y, Yu Q | title = Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 110 | issue = 27 | pages = 11121–11126 | date = July 2013 | pmid = 23784775 | doi = 10.1073/pnas.1300873110 | pmc = 3704014 | bibcode = 2013PNAS..11011121L | doi-access = free }}</ref> SNP rs7115089 was identified as influencing DNA methylation and expression of this locus, as well as and Body Mass Index (BMI).<ref name="Hawe_2022" /> In fact, SNP rs7115089 is strongly associated with BMI<ref>{{cite journal | vauthors = Yengo L, Sidorenko J, Kemper KE, Zheng Z, Wood AR, Weedon MN, Frayling TM, Hirschhorn J, Yang J, Visscher PM | title = Meta-analysis of genome-wide association studies for height and body mass index in ~700000 individuals of European ancestry | journal = Human Molecular Genetics | volume = 27 | issue = 20 | pages = 3641–3649 | date = October 2018 | pmid = 30124842 | doi = 10.1093/hmg/ddy271 | pmc = 6488973 }}</ref> and with genetic variants linked to other cardiovascular and metabolic traits in GWASs.<ref>{{cite journal | vauthors = Pulit SL, Stoneman C, Morris AP, Wood AR, Glastonbury CA, Tyrrell J, Yengo L, Ferreira T, Marouli E, Ji Y, Yang J, Jones S, Beaumont R, Croteau-Chonka DC, Winkler TW, Hattersley AT, Loos RJ, Hirschhorn JN, Visscher PM, Frayling TM, Yaghootkar H, Lindgren CM | title = Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry | journal = Human Molecular Genetics | volume = 28 | issue = 1 | pages = 166–174 | date = January 2019 | pmid = 30239722 | doi = 10.1093/hmg/ddy327 | pmc = 6298238 }}</ref><ref>{{cite journal | vauthors = Zhu Z, Guo Y, Shi H, Liu CL, Panganiban RA, Chung W, O'Connor LJ, Himes BE, Gazal S, Hasegawa K, Camargo CA, Qi L, Moffatt MF, Hu FB, Lu Q, Cookson WO, Liang L | title = Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank | journal = The Journal of Allergy and Clinical Immunology | volume = 145 | issue = 2 | pages = 537–549 | date = February 2020 | pmid = 31669095 | doi = 10.1016/j.jaci.2019.09.035 | pmc = 7010560 }}</ref><ref>{{cite journal | vauthors = Richardson TG, Sanderson E, Palmer TM, Ala-Korpela M, Ference BA, Davey Smith G, Holmes MV | title = Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis | journal = PLOS Medicine | volume = 17 | issue = 3 | pages = e1003062 | date = March 2020 | pmid = 32203549 | doi = 10.1371/journal.pmed.1003062 | pmc = 7089422 | doi-access = free }}</ref> New studies suggesting ''UBASH3B'' as a potential mediator of adiposity and cardiometabolic disease.<ref name="Hawe_2022" /> In addition, animal models demonstrated that ''UBASH3B'' expression is an indicator of caloric restriction that may drive programmed susceptibility to obesity and it is associated with other measures of adiposity in human peripherical blood.<ref>{{cite journal | vauthors = Konieczna J, Sánchez J, Palou M, Picó C, Palou A | title = Blood cell transcriptomic-based early biomarkers of adverse programming effects of gestational calorie restriction and their reversibility by leptin supplementation | journal = Scientific Reports | volume = 5 | issue = 1 | pages = 9088 | date = March 2015 | pmid = 25766068 | doi = 10.1038/srep09088 | pmc = 4357898 | bibcode = 2015NatSR...5.9088K }}</ref>