Editing Zebrafish (section)

=== Diabetes ===
Zebrafish pancreas development is very homologous to mammals, such as mice. The signaling mechanisms and way the pancreas functions are very similar. The pancreas has an endocrine compartment, which contains a variety of cells. Pancreatic PP cells that produce polypeptides, and β-cells that produce insulin are two examples of those such cells. This structure of the pancreas, along with the glucose homeostasis system, are helpful in studying diseases, such as diabetes, that are related to the pancreas. Models for pancreas function, such as fluorescent staining of proteins, are useful in determining the processes of glucose homeostasis and the development of the pancreas. Glucose tolerance tests have been developed using zebrafish, and can now be used to test for glucose intolerance or diabetes in humans. The function of insulin are also being tested in zebrafish, which will further contribute to human medicine. The majority of work done surrounding knowledge on glucose homeostasis has come from work on zebrafish transferred to humans.<ref name="Zang">{{cite journal |vauthors=Zang L, Maddison LA, Chen W |title=Zebrafish as a Model for Obesity and Diabetes |journal=Frontiers in Cell and Developmental Biology |volume=6 |issue=91 |page=91 |date=20 August 2018 |pmid=30177968 |pmc=6110173 |doi=10.3389/fcell.2018.00091 |doi-access=free}}</ref>