Editing List of fictional computers (section)

===2000s===
* '''Icarus''', '''Daedalus''', '''Helios''', '''Morpheus''' and '''The Oracle''' of ''[[Deus Ex (video game)|Deus Ex]]'' — see [[Deus Ex characters#Artificial intelligences|''Deus Ex'' characters]] (2000)
* '''Mainframe''', from ''[[Gunman Chronicles]]'' (later got a body) (2000)
* '''343 Guilty Spark''', monitor of Installation 04, in the video game trilogy ''[[Halo (video game)|Halo]]'', ''[[Halo 2]]'', and ''[[Halo 3]]'' (2001)
* '''Calculator''', the computer that controlled the bomb shelter Vault 0. It was not strictly an artificial intelligence, but rather a cyborg, because it was connected with several human brains. It appeared in the video game ''[[Fallout Tactics: Brotherhood of Steel]]'' (2001)
* '''[[Cortana (Halo)|Cortana]]''', a starship-grade "smart" AI of the UNSC and companion of the [[Master Chief (Halo)|Master Chief]] in the ''[[Halo (Franchise)|Halo]]'' video games (2001) (also the inspiration for the name of [[Cortana (software)|Microsoft's real-world personal assistant]] in [[Windows 10]])
* '''Deadly Brain''', a level boss on the second level of ''[[Oni (video game)|Oni]]'' (2001)
* The mascot of the "Hectic Hackers" basketball team in ''[[Backyard Basketball]]'' (2001)
* '''PETs''' (PErsonal Terminals), the cell-phone-sized computers that store Net-Navis in ''[[Mega Man Battle Network (video game)|Megaman Battle Network]]''. The PETs also have other features, such as a cell phone, e-mail checker and hacking device. (2001)
* '''Thiefnet computer''', Bentley the turtle's laptop from the ''[[Sly Cooper]]'' series (2002)
* '''Adam''', the computer intelligence from the [[Game Boy Advance]] game ''[[Metroid Fusion]]'' (2002)
* '''Aura''' and '''Morganna''', from the ''[[.hack]]'' series, the Phases that serve Morganna, and the Net Slum AIs (2002)
* '''Dr. Carroll''', from the [[Nintendo 64]] game ''[[Perfect Dark]]'' (2002)
* '''The Controller''', an AI that dictates virtually everything in the world "Layered", from ''[[Armored Core 3]]'' (2002)
* '''ADA''', from the video games ''[[Zone of the Enders]]'' (2001) and ''[[Zone of the Enders: The 2nd Runner]]'' (2003)
* '''IBIS''', the malevolent AI found within the second Layered, within the game ''[[Silent Line: Armored Core]]'' (2003)
* '''2401 Penitent Tangent''', monitor of Delta Halo in ''[[Halo 2]]'' (2004)
* '''Angel''' (original Japanese name was "Tenshi"), artificial intelligence of the alien cruiser ''Angelwing'' in the game ''[[Nexus: The Jupiter Incident]]'' (2004)
* '''Durga/Melissa/Yasmine''', the shipboard AI of the U.N.S.C. ''Apocalypso'' in the [[Alternate Reality Game]] ''[[I Love Bees]]'' (promotional game for the ''[[Halo 2]]'' video game) (2004)
* '''The Mechanoids''', a race of fictional artificial intelligence from the game ''[[Nexus: The Jupiter Incident]]'' who rebelled against their creators and seek to remake the universe to fit their needs. (2004)
* '''TEC-XX''', the main computer in the X-naut Fortress in ''[[Paper Mario: The Thousand-Year Door]]'' (2004)
* '''Overwatch''' or Overwatch Voice,  is an A.I. that acts as the field commander and public announcer of the Combine Overwatch on Earth. It talks in a distinctive flat, clinical tone using a female voice, and its speech is disjointed in a fashion similar to telephone banking systems. It euphemistically uses a type of medically inspired Newspeak to describe citizen disobedience, resistance activity and coercive and violent Combine tactics in the context of a bacterial infection and treatment. In the video game ''[[Half-Life (series)|Half-Life 2]]'' (2004-2007)
* '''Dvorak''', an infinite-state machine created by Abrahim Zherkezhi used to create algorithms that would be used for Information Warfare in ''[[Tom Clancy's Splinter Cell: Chaos Theory]]'' (2005)
* '''TemperNet''', is a machine hive-mind, originally created as an anti-mutant police force. It eventually went rogue and pursued the eradication of all biological life on Earth. It served as a minor antagonist in the now defunct post-apocalyptic vehicular MMORPG ''[[Auto Assault]]''. (2006)
* '''Animus''', the computer system used to recover memories from the ancestors of an individual in the video game series ''[[Assassin's Creed]]'' (2007)
* '''[[Aurora Unit]]''', biological/mechanical computers distributed throughout the galaxy in ''[[Metroid Prime 3: Corruption]]'' (2007)
* '''The Catalyst''', an ancient AI that serves as the architect and overseer of the Reapers (the antagonists of ''[[Mass Effect]]''). Also known as '''the Intelligence''' to its creators, the Leviathans, it was originally created to oversee relationships between organic and synthetic life as a whole, but came to realize that so long as they remained separate organics and synthetics would seek to destroy each other in the long term. To prevent this, it sets into motion the Cycle of Extinction until a perfect solution can be found, which takes its form in the "Synthesis" ending of ''[[Mass Effect 3]]'' wherein all organic and synthetic life across the galaxy is fused into an entirely new form of life with the strengths of both but the weaknesses of neither. (2007)
* '''[[GLaDOS]]''' (Genetic Lifeform and Disk Operating System), AI at the Aperture Science Enrichment Center in the Valve games ''[[Portal (video game)|Portal]]'' and ''[[Portal 2]]''. Humorously psychotic scientific computer, known for killing almost everyone in the Enrichment Center, and her love of cake. (2007)
* '''I.R.I.S.''', the super computer in ''[[Ratchet & Clank Future: Tools of Destruction]]'' on the Kreeli comet (2007)
* '''Mendicant Bias''', an intelligence-gathering AI created by the extinct [[Forerunners (Halo)|Forerunner]] race during their war with the all-consuming [[Flood (Halo)|Flood]] parasite, as revealed in ''[[Halo 3]]''. Its purpose was to observe the Flood in order to determine the best way to defeat it, but the AI turned on its creators after deciding that the Flood's ultimate victory was in-line with natural order. (2007)
* '''Offensive Bias''', a military AI created by the Forerunners to hold off the combined threat of the Flood and Mendicant Bias until the Halo superweapons could be activated. ''[[Halo 3]]'' (2007)
* '''QAI''', an AI created by Gustaf Brackman in [[Supreme Commander (game)|Supreme Commander]], serves as a military advisor for the Cybran nation and as one of the villains in ''[[Supreme Commander: Forged Alliance]]'' (2007)
* '''Sovereign''', the given name for the main antagonist of ''[[Mass Effect]]''. Its true name, as revealed by a squad member in the sequel, is "Nazara". Though it speaks as though of one mind, it claims to be in and of itself "a nation, free of all weakness", suggesting that it houses multiple consciousnesses. It belongs to an ancient race bent on the cyclic extinction of all sentient life in the galaxy, known as the Reapers. (2007)
* '''John Henry Eden''', AI and self-proclaimed President of the United States in ''[[Fallout 3]]'' (2008)
* '''LEGION''' (Logarithmically Engineered Governing Intelligence Of Nod), appeared in ''[[Command and Conquer 3: Kane's Wrath]]''; this AI was created as the successor to the Brotherhood of Nod's previous AI, CABAL. (2008)
* '''CL4P-TP''', a small robot AI assistant with an attitude and possibly ninja training, commonly referred to as "Clap Trap", from the game ''[[Borderlands (video game)|Borderlands]]'' (2009)
* '''The Guardian Angel''', the satellite/AI guiding the player in ''[[Borderlands (video game)|Borderlands]]'' (2009)
* '''Serina''', the shipboard AI of the UNSC carrier ''Spirit of Fire'' in ''[[Halo Wars]]'', and a playable leader in that game and its sequel, ''[[Halo Wars 2]]'' (2009)