Editing Sjögren's disease (section)

===Mortality===
Published studies on the survival of Sjögren's disease patients have been limited in varied respects, perhaps owing to the relatively small sample sizes and the fact that secondary Sjögren's disease is associated with other autoimmune diseases.
A 2010 study found a slight increase in [[mortality rate]]s of Sjögren's patients in comparison with the remainder of the population.<ref name=Voulgarelis2010/> A 2016 study found that primary Sjögren's was not associated with an increase in all-cause mortality as compared with the general population, but that a subset of patients with extraglandular involvement, vasculitis, hypocomplementaemia, and cryoglobulinaemia may be at increased risk of mortality.<ref>{{cite journal |last1=Singh |first1=Abha G. |last2=Singh |first2=Siddharth |last3=Matteson |first3=Eric L. |title=Rate, risk factors and causes of mortality in patients with Sjögren's syndrome: a systematic review and meta-analysis of cohort studies |journal=Rheumatology |date=27 September 2015 |volume=55 |issue=3 |pages=450–460 |doi=10.1093/rheumatology/kev354 |pmid=26412810 |pmc=5009445 |doi-access=free }}</ref> A 2021 metaanalysis showed a 46% increase in mortality, with significantly greater mortality risk in patients with older age, male gender, vasculitis, interstitial lung disease, low complements, positive anti-La/SSB and cryoglobulinaemia.<ref>{{cite journal |last1=Huang |first1=Hong |last2=Xie |first2=Wenhui |last3=Geng |first3=Yan |last4=Fan |first4=Yong |last5=Zhang |first5=Zhuoli |title=Mortality in patients with primary Sjögren's syndrome: a systematic review and meta-analysis |journal=Rheumatology |date=1 September 2021 |volume=60 |issue=9 |pages=4029–4038 |doi=10.1093/rheumatology/keab364 |pmid=33878179 }}</ref>

Among those without other autoimmune disorders, [[life expectancy]] is unchanged.<ref name="Sin2016">{{cite journal| last1= Singh| first1=AG|last2=Singh|first2=S|last3=Matteson|first3=EL|date=March 2016|title=Rate, risk factors and causes of mortality in patients with Sjögren's syndrome: a systematic review and meta-analysis of cohort studies |journal= Rheumatology| volume= 55| issue= 3| pages=450–60|doi=10.1093/rheumatology/kev354|pmid=26412810|pmc=5009445}}</ref>