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===Additives=== Compounds can be added in both organic and conventional hydroponic systems to improve nutrition acquisition and uptake by the plant''.'' Chelating agents and humic acid have been shown to increase nutrient uptake.<ref>{{cite journal|last1=Adania|first1=Fabrizio|last2=Genevinia|first2=Pierluigi|last3=Zaccheoa|first3=Patrizia|last4=Zocchia|first4=Graziano|date=1998|title=The effect of commercial humic acid on tomato plant growth and mineral nutrition|journal=Journal of Plant Nutrition|volume=21|issue=3|pages=561β575|doi=10.1080/01904169809365424|bibcode=1998JPlaN..21..561A }}</ref>{{sfn|Jones Jr.|2016|p={{pn|date=March 2025}}}} Additionally, plant growth promoting rhizobacteria (PGPR), which are regularly utilized in field and greenhouse agriculture, have been shown to benefit hydroponic plant growth development and nutrient acquisition.<ref>{{cite journal |last1=Lee |first1=Seungjun |last2=Lee |first2=Jiyoung |title=Beneficial bacteria and fungi in hydroponic systems: Types and characteristics of hydroponic food production methods |journal=Scientia Horticulturae |date=November 2015 |volume=195 |pages=206β215 |doi=10.1016/j.scienta.2015.09.011 |bibcode=2015ScHor.195..206L }}</ref> Some PGPR are known to increase nitrogen fixation. While nitrogen is generally abundant in hydroponic systems with properly maintained fertilizer regimens, ''Azospirillum'' and ''Azotobacter'' genera can help maintain mobilized forms of nitrogen in systems with higher microbial growth in the rhizosphere.<ref name=":5">{{Cite thesis |degree=Bachelor |last=Soderstrom |first=Linus |date=2020|title=Plant-Growth Promoting Rhizobacteria in Soilless Cannabis Cropping Systems |url=https://stud.epsilon.slu.se/16079/11/soderstrom_l_200923.pdf |publisher=Sveriges lantbruksuniversitet}}</ref> Traditional fertilizer methods often lead to high accumulated concentrations of nitrate within plant tissue at harvest. ''Rhodopseudo-monas palustris'' has been shown to increase nitrogen use efficiency, increase yield, and decrease nitrate concentration by 88% at harvest compared to traditional hydroponic fertilizer methods in leafy greens.<ref>{{Cite journal |author=ShuHua Hsu |author2=KaiJiun Lo |author3=Wei Fang |author4=HuuSheng Lur |author5=ChiTe Liu |date=2015|title=Application of phototrophic bacterial inoculant to reduce nitrate content in hydroponic leafy vegetables|url=https://www.cabdirect.org/cabdirect/abstract/20153203178 |url-access=subscription |journal=Crop, Environment, and Bioinformatics|volume=12|pages=30β41}}</ref> Many ''Bacillus'' spp., ''Pseudomonas'' spp. and ''Streptomyces'' spp. convert forms of phosphorus in the soil that are unavailable to the plant into soluble anions by decreasing soil pH, releasing phosphorus bound in chelated form that is available in a wider pH range, and mineralizing organic phosphorus.<ref name=":5" /> Some studies have found that ''Bacillus'' inoculants allow hydroponic leaf lettuce to overcome high salt stress that would otherwise reduce growth.<ref>{{cite journal |last1=Moncada |first1=Alessandra |last2=Vetrano |first2=Filippo |last3=Miceli |first3=Alessandro |title=Alleviation of Salt Stress by Plant Growth-Promoting Bacteria in Hydroponic Leaf Lettuce |journal=Agronomy |date=6 October 2020 |volume=10 |issue=10 |pages=1523 |doi=10.3390/agronomy10101523 |doi-access=free |bibcode=2020Agron..10.1523M |hdl=10447/437141|hdl-access=free }}</ref> This can be especially beneficial in regions with high electrical conductivity or salt content in their water source. This could potentially avoid costly reverse osmosis filtration systems while maintaining high crop yield.
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