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=== Bipolar disorder === Aspirin has been repurposed as an add-on treatment for depressive episodes in subjects with [[bipolar disorder]].<ref name="repurposed2021"/> However, meta-analytic evidence is based on very few studies and does not suggest any efficacy of aspirin in the treatment of bipolar depression.<ref name="repurposed2021"/> Thus, notwithstanding the biological rationale, the clinical perspectives of aspirin and anti-inflammatory agents in the treatment of bipolar depression remain uncertain.<ref name="repurposed2021"/>
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