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==Defense against fungi== It has been hypothesized that warm-bloodedness evolved in mammals and birds as a defense against [[fungal infection]]s. Very few fungi can survive the body temperatures of warm-blooded animals. By comparison, insects, reptiles, and amphibians are plagued by fungal infections.<ref>{{cite web|url=https://www.newscientist.com/article/mg21228411.700-killer-fungi-made-us-hotblooded.html#.UeTeVY0wd8E|year=2011|title=Killer Fungi Made us Hotblooded|last=Dunn |first=Rob|work=New Scientist|access-date=27 April 2016}}{{subscription required}}</ref><ref>Aviv Bergman, Arturo Casadevall. 2010. [https://mbio.asm.org/content/1/5/e00212-10.full?sid=eb1e9d14-ab01-4d2f-9e5b-623a13ae278f Mammalian Endothermy Optimally Restricts Fungi and Metabolic Costs]. mBio Nov 2010, 1 (5) e00212-10. {{doi|10.1128/mBio.00212-10}}</ref><ref>Vincent A. Robert, Arturo Casadevall. 2009. [https://academic.oup.com/jid/article/200/10/1623/881601 Vertebrate Endothermy Restricts Most Fungi as Potential Pathogens]. ''[[The Journal of Infectious Diseases]]'', Volume 200, Issue 10, 15 November 2009, Pages 1623β1626. {{doi|10.1086/644642}}</ref><ref>Casadevall A (2012) [https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1002808 Fungi and the Rise of Mammals]. PLoS Pathog 8(8): e1002808. {{doi|10.1371/journal.ppat.1002808}}</ref> Warm-blooded animals have a defense against pathogens contracted from the environment, since environmental pathogens are not adapted to their higher internal temperature.<ref>{{Cite journal|last1=Robert|first1=Vincent A.|last2=Casadevall|first2=Arturo|date=2009-11-15|title=Vertebrate Endothermy Restricts Most Fungi as Potential Pathogens|journal=[[The Journal of Infectious Diseases]]|language=en|volume=200|issue=10|pages=1623β1626|doi=10.1086/644642|pmid=19827944|issn=0022-1899|doi-access=free}}</ref>
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