Editing Trifluoperazine (section)

== Side effects ==
Its use in  many parts of the world has declined because of highly frequent and severe early and late [[tardive dyskinesia]], a type of  [[extrapyramidal symptom]].  The annual development rate of tardive dyskinesia may be as high as 4%.{{Citation needed|date=April 2009}}

A 2004 [[meta-analysis]] of the studies on trifluoperazine found that it is more likely than placebo to cause extrapyramidal side effects such as [[akathisia]], [[dystonia]], and [[Parkinsonism]].<ref name="Marq">{{cite journal |vauthors=Marques LO, Lima MS, Soares BG | title = Trifluoperazine for schizophrenia| journal = Cochrane Database of Systematic Reviews| issue = 1| pages = CD003545| year = 2004| volume = 2004| pmid = 14974020| doi = 10.1002/14651858.CD003545.pub2| pmc = 7003674}}</ref> It is also more likely to cause [[somnolence]] and anticholinergic side effects such as [[Red eye (medicine)|red eye]] and [[xerostomia]] (dry mouth).<ref name="Marq"/> All antipsychotics can cause the rare and sometimes fatal [[neuroleptic malignant syndrome]].<ref>{{cite journal|vauthors=Smego RA, Durack DT | title = The neuroleptic malignant syndrome| journal = Archives of Internal Medicine| volume = 142| issue = 6| pages = 1183–5| date=June 1982| pmid = 6124221| doi = 10.1001/archinte.142.6.1183}}</ref> Trifluoperazine can lower the seizure threshold.<ref>{{cite journal|vauthors=Hedges D, Jeppson K, Whitehead P | title = Antipsychotic medication and seizures: a review| journal = Drugs of Today| volume = 39| issue = 7| pages = 551–7| date=July 2003| pmid = 12973403| doi = 10.1358/dot.2003.39.7.799445}}</ref> The [[antimuscarinic]] action of trifluoperazine can cause excessive dilation of the pupils ([[mydriasis]]), which increases the chances of patients with [[hyperopia]] developing [[glaucoma]].<ref>{{cite journal | vauthors = Boet DJ | title = Toxic effects of phenothiazines on the eye | journal = Documenta Ophthalmologica. Advances in Ophthalmology | volume = 28 | issue = 1 | pages = 1–69 | date = July 1970 | pmid = 5312274 | doi = 10.1007/BF00153873 | hdl-access = free | s2cid = 26145461 | hdl = 1765/26543 }}</ref>