Editing Takamine Jōkichi (section)

===United States===
[[File:Takadiastase1905usa.jpg|left|thumb|Taka-diastase advertisement in 1905]]
In 1884, Takamine went as co-commissioner of the [[World Cotton Centennial|World Cotton Centennial Exposition]] to [[New Orleans]], where he met [[Lafcadio Hearn]] and 18 year old [[Caroline Takamine Beach|Caroline Field Hitch]], his future wife. In 1885, he became the temporary Chief of the Japanese Patent Office and helped to lay the foundations of patent administration. He founded he Tokyo Artificial Fertilizer Company, importing large amounts of [[phosphate]]
from [[Charleston, South Carolina]]. In 1890, he emigrated with his wife and two sons to Chicago.<ref name="shurtleff"/>{{rp|6}} 

He established his own research laboratory in [[New York City]] but licensed the exclusive production rights for takadiastase to one of the largest US pharmaceutical companies, [[Parke-Davis]].<ref name="Odagiri-Goto">{{Cite book |last=Odagiri |first=Hiroyuki |title=Technology and Industrial Development in Japan |publisher=Clarendon Press, Oxford |year=1996 |isbn=978-0-19-828802-2 |pages=214}}</ref> This turned out to be a shrewd move as  he became a millionaire in a relatively short time and by the early 20th century was estimated to be worth $30 million.<ref name="Pulvers" />{{dead link|date=July 2023}}

In 1894, Takamine applied for, and was granted, a US patent titled "Process of Making Diastatic Enzyme" ({{US Patent|525,823}}),  the first patent on a microbial enzyme in the United States.<ref name="MDD"/><ref>{{Cite web |last=Takamine |first=Jokiohi |date=1894 |title=Process of making diastatic enzyme |url=https://patents.google.com/patent/US525823 |access-date=24 January 2016 |website=Google Patents |archive-date=3 March 2016 |archive-url=https://web.archive.org/web/20160303122819/http://www.google.com/patents/US525823 |url-status=live }}</ref>

In 1901, he isolated and purified the hormone [[adrenaline]], which became the first effective bronchodilator for [[asthma]] from animal glands, becoming the first to accomplish this for a glandular hormone.<ref name="Yamashima">{{Cite journal |last=Yamashima T |year=2003 |title=Jokichi Takamine (1854-1922), the samurai chemist, and his work on adrenalin |journal=J Med Biogr |volume=11 |issue=2 |pages=95–102 |doi=10.1177/096777200301100211 |pmid=12717538 |s2cid=32540165}}</ref><ref>{{Cite journal |last=Bennett M |year=1999 |title=One hundred years of adrenaline: the discovery of autoreceptors |journal=Clin Auton Res |volume=9 |issue=3 |pages=145–59 |doi=10.1007/BF02281628 |pmid=10454061 |s2cid=20999106}}</ref> 

In 1904, the [[Emperor Meiji]] of Japan honored Takamine with an unusual gift. In the context of the St. Louis World Fair ([[Louisiana Purchase Exposition]]), the Japanese government had replicated a historical Japanese structure, the "Pine and Maple Palace" (''Shofu-den''), modelled after the Kyoto Imperial Coronation Palace of 1,300 years ago. This structure was given to Dr. Takamine in grateful recognition of his efforts to further friendly relations between Japan and the United States.<ref name="nyt47">{{Cite news |last=Estrow |first=Milton |url=https://www.nytimes.com/1947/09/28/archives/japanese-palace-replica-near-monticello-now-open-to-public.html?sq=Japanese+Palace%253B+Replica+near+monticello&scp=1&st=p |title=Japanese Palace; Replica Near Monticello Now Open to Public |newspaper=New York Times |date=September 28, 1947 |access-date=July 23, 2018 |archive-date=July 23, 2018 |archive-url=https://web.archive.org/web/20180723065553/https://www.nytimes.com/1947/09/28/archives/japanese-palace-replica-near-monticello-now-open-to-public.html?sq=Japanese+Palace%253B+Replica+near+monticello&scp=1&st=p |url-status=live }}</ref>  He had the structure transported in sections from [[Missouri]] to his summer home in upstate New York, seventy-five miles north of [[New York City]]. In 1909, the structure served as a guest house for [[Prince Kuni Kuniyoshi]] and Princess Kuni of Japan, who were visiting the area.<ref>[https://query.nytimes.com/gst/abstract.html?res=9805E2D81F31E733A25753C2A96F9C946897D6CF&scp=10&sq=Takamine&st=p "Kuni in Japanese House; Host of Prince, Dr. Takamine, Has Japanese Structures of St. Louis Fair,"] {{Webarchive|url=https://web.archive.org/web/20160303225934/http://query.nytimes.com/gst/abstract.html?res=9805E2D81F31E733A25753C2A96F9C946897D6CF&scp=10&sq=Takamine&st=p |date=2016-03-03 }} ''New York Times.'' September 20, 1909.</ref>  Although the property was sold in 1922, the reconstructed structure remained in its serene setting. In 2008, it still continues to be one of the undervalued tourist attractions of New York's Sullivan County.<ref>{{Cite web |date=2008-02-26 |title=Sho Fu Den |url=http://www.shofuden.com/index.php?page=history |access-date=2023-07-06 |archive-date=2008-02-26 |archive-url=https://web.archive.org/web/20080226053322/http://www.shofuden.com/index.php?page=history |url-status=bot: unknown }}</ref>

In 1905, Takamine founded the [[Nippon Club (New York)|Nippon Club]], which was for many years located at [[161 West 93rd Street]] in [[Manhattan]].<ref name="nyt2001">{{Cite news |last=Gray |first=Christopher |date=2001-09-30 |title=Streetscapes/161 West 93rd Street; A Building That Recalls the Days After Pearl Harbor |language=en-US |work=The New York Times |url=https://www.nytimes.com/2001/09/30/realestate/streetscapes-161-west-93rd-street-building-that-recalls-days-after-pearl-harbor.html |access-date=2023-07-06 |issn=0362-4331 |archive-date=2023-05-28 |archive-url=https://web.archive.org/web/20230528151426/https://www.nytimes.com/2001/09/30/realestate/streetscapes-161-west-93rd-street-building-that-recalls-days-after-pearl-harbor.html |url-status=live }}</ref>

Takamine devoted his life to maintaining goodwill between the US and Japan.<ref name="katz">{{Cite book |last=Katz |first=Stan S. |title=The Art of Peace |publisher=Horizon Productions |year=2019 |edition=expanded |pages=32, 200, 216 note 5, 219 note 13, 364, 365, 370, 384 note 11}}</ref><ref>{{Cite web |date=2020 |title=Introduction to The Art of Peace: the illustrated biography of Prince Iyesato Tokugawa |url=https://theemperorandthespy.com/2020/04/the-art-of-peace-the-illustrated-biography-on-prince-iyesato-tokugawa/ |website=TheEmperorAndTheSpy.com |access-date=2020-08-17 |archive-date=2020-08-05 |archive-url=https://web.archive.org/web/20200805132921/https://theemperorandthespy.com/2020/04/the-art-of-peace-the-illustrated-biography-on-prince-iyesato-tokugawa/ |url-status=live }}</ref>

In 1912, the [[mayor of Tokyo]] ([[Yukio Ozaki]]) and Jokichi Takamine gifted  [[cherry blossom]] trees, which were planted in the [[West Potomac Park]] surrounding the [[Tidal Basin]] in [[Washington, DC]].<ref>{{Cite web |title=Cherry Trees in Washington DC |url=http://www.islands.ne.jp/8686/column/20010315.html |url-status=dead |archive-url=https://web.archive.org/web/20070227082826/http://www.islands.ne.jp/8686/column/20010315.html |archive-date=2007-02-27}}</ref>

A 1915 photo presents Jōkichi Takamine as the host for a banquet honoring the visiting Japanese diplomat [[Shibusawa Eiichi|Baron Eiichi Shibusawa]]. This illustration is linked to Jōkichi Takamine's involvement in the gifting of the [[cherry blossom]] trees to Washington, DC in 1912, which has evolved into the [[National Cherry Blossom Festival]] which is celebrated yearly.<ref name="katz2">{{Cite book |last=Katz |first=Stan S. |title=The Art of Peace |publisher=Horizon Productions |year=2019 |isbn=978-0-9903349-6-5 |location=California |pages=209, 225–6, 373–4, 379}}</ref><ref>{{Cite web |date=2020 |title=1915 Photo: Theodore Roosevelt & William Howard Taft honor Baron Shibusawa Eiichi during his important diplomatic visit to the United States. |url=https://theemperorandthespy.com/2020/02/history-has-its-mysteries-recently-discovered-1915-photo-theodore-roosevelt-william-howard-taft-honor-baron-shibusawa-during-his-important-diplomatic-visit-to-the-united-states/ |access-date=2020-06-04 |archive-date=2023-03-28 |archive-url=https://web.archive.org/web/20230328192833/https://theemperorandthespy.com/2020/02/history-has-its-mysteries-recently-discovered-1915-photo-theodore-roosevelt-william-howard-taft-honor-baron-shibusawa-during-his-important-diplomatic-visit-to-the-united-states/ |url-status=live }}</ref>