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Stevens–Johnson syndrome
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=== Infections === The second most common cause of SJS and TEN is infection, particularly in children. This includes [[upper respiratory infections]], [[otitis media]], [[pharyngitis]], and [[Epstein–Barr virus]], ''[[Mycoplasma pneumoniae]]'' and [[cytomegalovirus]] infections. The routine use of medicines such as [[antibiotics]], [[antipyretics]] and [[analgesics]] to manage infections can make it difficult to identify if cases were caused by the infection or medicines taken.<ref>{{cite journal|last1=Bentley|first1=John|last2=Sie|first2=David|title=Stevens-Johnson syndrome and toxic epidermal necrolysis|journal=The Pharmaceutical Journal|date=October 8, 2014|volume=293|issue=7832|url=http://www.pharmaceutical-journal.com/learning/cpd-article/stevens-johnson-syndrome-and-toxic-epidermal-necrolysis/20066728.cpdarticle|access-date=October 8, 2014|url-status=live|archive-url=https://web.archive.org/web/20141012190345/http://www.pharmaceutical-journal.com/learning/cpd-article/stevens-johnson-syndrome-and-toxic-epidermal-necrolysis/20066728.cpdarticle|archive-date=October 12, 2014}}</ref> Viral diseases reported to cause SJS include: [[herpes simplex virus]] (possibly; is debated), AIDS, [[coxsackievirus]], [[influenza]], [[hepatitis]], and [[mumps]].<ref name="Medscape Ref SJS" /> In pediatric cases, Epstein–Barr virus and enteroviruses have been associated with SJS.<ref name="Medscape Ref SJS" /> Recent upper respiratory tract infections have been reported by more than half of patients with SJS.<ref name="Medscape Ref SJS" /> Bacterial infections linked to SJS include group A beta-hemolytic streptococci, [[diphtheria]], [[brucellosis]], [[lymphogranuloma venereum]], [[Mycobacterium|mycobacteria]], ''[[Mycoplasma pneumoniae]]'', [[Rickettsial disease|rickettsial infections]], [[tularemia]], and [[typhoid]].<ref name="Medscape Ref SJS" /> Fungal infections with [[coccidioidomycosis]], [[dermatophytosis]] and [[histoplasmosis]] are also considered possible causes.<ref name="Medscape Ref SJS" /> [[Malaria]] and [[trichomoniasis]], protozoal infections, have also been reported as causes.<ref name="Medscape Ref SJS" />
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