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Protein phosphatase
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===PPM=== The PPM family, which includes PP2C and pyruvate dehydrogenase phosphatase, are enzymes with Mn<sup>2+</sup>/Mg<sup>2+</sup> metal ions that are resistant to classic inhibitors and toxins of the PPP family. Unlike most PPPs, PP2C exists in only one subunit but, like PTPs, it displays a wide variety of structural domains that confer unique functions. In addition, PP2C does not seem to be evolutionarily related to the major family of Ser/Thr PPs and has no sequence homology to ancient PPP enzymes. The current assumption is that PPMs evolved separately from PPPs but converged during evolutionary development.
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