Editing Nucleolus (section)

== Sequestration of proteins ==
In addition to its role in ribosomal biogenesis, the nucleolus is known to capture and immobilize proteins, a process known as nucleolar detention. Proteins that are [[Detention center (cell biology)|detained in the nucleolus]] are unable to diffuse and to interact with their binding partners. Targets of this [[Post-translational regulation|post-translational regulatory mechanism]] include [[Von Hippel–Lindau tumor suppressor|VHL]], [[Promyelocytic leukemia protein|PML]], [[MDM2]], [[POLD1]], [[RELA|RelA]], [[HAND1]] and [[Telomerase reverse transcriptase|hTERT]], among many others. It is now known that [[long noncoding RNA]]s originating from [[intergenic region]]s of the nucleolus are responsible for this phenomenon.<ref>{{cite journal | vauthors = Audas TE, Jacob MD, Lee S | title = Immobilization of proteins in the nucleolus by ribosomal intergenic spacer noncoding RNA | journal = Molecular Cell | volume = 45 | issue = 2 | pages = 147–57 | date = January 2012 | pmid = 22284675 | doi = 10.1016/j.molcel.2011.12.012 | doi-access = free }}</ref>