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===Detection of resistance=== Owing to the widespread [[Macrolide|macrolide resistance]], samples that are positive for Mgen should ideally be followed up with an assay capable of detecting mutations that mediate antimicrobial resistance. The European Guideline on Mgen infections recommend complementing the molecular detection of Mgen with an assay capable of detecting macrolide resistance-associated mutations. Furthermore, molecular assays for quinolone resistance-associated mutations are available at specialised laboratories in suspected treatment failure due to treatment with moxifloxacin.<ref>{{Cite journal |last1=Jensen |first1=J.S. |last2=Cusini |first2=M. |last3=Gomberg |first3=M. |last4=Moi |first4=H. |last5=Wilson |first5=J. |last6=Unemo |first6=M. |date=May 2022 |title=2021 European guideline on the management of Mycoplasma genitalium infections |url=https://onlinelibrary.wiley.com/doi/10.1111/jdv.17972 |journal=Journal of the European Academy of Dermatology and Venereology |language=en |volume=36 |issue=5 |pages=641β650 |doi=10.1111/jdv.17972 |pmid=35182080 |issn=0926-9959}}</ref>
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