Editing Marfan syndrome (section)

===Cardiovascular system===
The most serious signs and symptoms associated with Marfan syndrome involve the [[circulatory system|cardiovascular system]]: undue [[fatigue (medical)|fatigue]], [[dyspnea|shortness of breath]], [[heart palpitations]], [[tachycardia|racing heartbeats]], or [[angina pectoris|chest pain]] radiating to the back, shoulder, or arm. Cold arms, hands, and feet can also be linked to MFS because of inadequate circulation. A [[heart murmur]], abnormal reading on an [[electrocardiogram|ECG]], or symptoms of [[angina pectoris|angina]] can indicate further investigation. The signs of regurgitation from [[prolapse]] of the mitral or aortic valves (which control the flow of blood through the heart) result from [[familial thoracic aortic aneurysm|cystic medial degeneration]] of the valves, which is commonly associated with MFS (see [[mitral valve prolapse]], [[aortic regurgitation]]). However, the major sign that would lead a doctor to consider an underlying condition is a [[Annuloaortic ectasia|dilated aorta]] or an [[aortic aneurysm]]. Sometimes, no heart problems are apparent until the weakening of the connective tissue (cystic medial degeneration) in the ascending aorta causes an aortic aneurysm or [[aortic dissection]], a surgical emergency. An aortic dissection is most often fatal and presents with pain radiating down the back, giving a tearing sensation.<ref>{{Cite web |title=Aortic dissection - Symptoms and causes |url=https://www.mayoclinic.org/diseases-conditions/aortic-dissection/symptoms-causes/syc-20369496 |access-date=2022-10-09 |website=Mayo Clinic |language=en |archive-date=2022-10-09 |archive-url=https://web.archive.org/web/20221009080040/https://www.mayoclinic.org/diseases-conditions/aortic-dissection/symptoms-causes/syc-20369496 |url-status=live }}</ref>

Because underlying connective tissue abnormalities cause MFS, the incidence of [[Wound dehiscence|dehiscence]] of prosthetic mitral valve is increased.<ref name="Braunwald-2005">{{cite book|author=Zipes, Libby Bonow Braunwald| title=Braunwald's Heart Disease ~ A Textbook of Cardiovascular Medicine, Seventh Edition|publisher=Elseview Saunders|year=2005|location=United States of America|page=1894|isbn=978-0-7216-0509-8}}</ref> Care should be taken to attempt repair of damaged heart valves rather than replacement.<ref>{{Cite journal |last1=Mick |first1=Stephanie L. |last2=Keshavamurthy |first2=Suresh |last3=Gillinov |first3=A. Marc |date=May 2015 |title=Mitral valve repair versus replacement |journal=Annals of Cardiothoracic Surgery |volume=4 |issue=3 |pages=230–237 |doi=10.3978/j.issn.2225-319X.2015.03.01 |issn=2225-319X |pmc=4533076 |pmid=26309824}}</ref>