Editing Iodothyronine deiodinase (section)

== Types ==

{{infobox protein
| Name = Type I iodothyronine deiodinase
| caption = 
| image = 
| width = 
| HGNCid = 2883
| Symbol = DIO1
| AltSymbols = TXDI1
| EntrezGene = 1733
| OMIM = 147892
| RefSeq = NM_000792
| UniProt = P49895
| PDB = 
| ECnumber = 1.21.99.3
| Chromosome = 1
| Arm = p
| Band = 32
| LocusSupplementaryData = -p33
}}
{{infobox protein
| Name = [[DIO2|Type II iodothyronine deiodinase]]
| caption = 
| image = 
| width = 
| HGNCid = 2884
| Symbol = [[DIO2]]
| AltSymbols = TXDI2, SelY
| EntrezGene = 1734
| OMIM = 601413
| RefSeq = NM_000793
| UniProt = Q92813
| PDB = 
| ECnumber = 1.21.99.4
| Chromosome = 14
| Arm = q
| Band = 24.2
| LocusSupplementaryData = -24.3
}}
{{infobox protein
| Name = [[Thyroxine 5-deiodinase|Type III iodothyronine deiodinase]]
| caption = 
| image = 
| width = 
| HGNCid = 2885
| Symbol = DIO3
| AltSymbols = TXDI3
| EntrezGene = 1735
| OMIM = 601038
| RefSeq = NM_001362
| UniProt = P55073
| PDB = 4TR3
| ECnumber = 1.97.1.11
| Chromosome = 14
| Arm = q
| Band = 32
| LocusSupplementaryData = 
}}

In most vertebrates, there are three types of enzymes that can deiodinate [[thyroid hormones]]:

{| class="wikitable"
! Type !! Location !! Function
 |- 
 | type I (DI) || is commonly found in the [[liver]] and [[kidney]] || DI can deiodinate both rings<ref name="pmid8187873">{{cite journal | vauthors = Moreno M, Berry MJ, Horst C, Thoma R, Goglia F, Harney JW, Larsen PR, Visser TJ | display-authors = 6 | title = Activation and inactivation of thyroid hormone by type I iodothyronine deiodinase | journal = FEBS Letters | volume = 344 | issue = 2–3 | pages = 143–6 | date = May 1994 | pmid = 8187873 | doi = 10.1016/0014-5793(94)00365-3 | doi-access = free }}</ref>
 |- 
 | [[DIO2|type II deiodinase (DII)]] || is found in the [[heart]], skeletal muscle, CNS, [[fat]], [[thyroid]], and [[pituitary]]<ref name="urlDeiodinases | National Academy of Hypothyroidism">{{cite web | url = http://nahypothyroidism.org/deiodinases/ | title = Deiodinases | author =  Holtorf K | year = 2012 | publisher = National Academy of Hypothyroidism  }}</ref>  || DII can only deiodinate the outer ring of the [[prohormone]] [[thyroxine]] and is the major activating enzyme (the already inactive [[reverse triiodothyronine]] is also  degraded further by DII)
 |- 
 | [[Thyroxine 5-deiodinase|type III deiodinase (DIII)]] || found in the fetal tissue and the [[placenta]]; also present throughout the brain, except in the pituitary<ref>{{cite journal | vauthors = Kaplan MM | title = The role of thyroid hormone deiodination in the regulation of hypothalamo-pituitary function | journal = Neuroendocrinology | volume = 38 | issue = 3 | pages = 254–60 | date = March 1984 | pmid = 6371572 | doi = 10.1159/000123900 }}</ref> || DIII can only deiodinate the inner ring of [[thyroxine]] or [[triiodothyronine]] and is the major inactivating enzyme
|}