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===Complications=== [[Splenomegaly|Spleen enlargement]] is common in the second and third weeks, although this may not be apparent on [[physical examination]]. Rarely the spleen may rupture.<ref>{{cite web | title = Infectious Mononucleosis | date = 19 November 2019 | publisher = Johns Hopkins Medicine | url = https://www.hopkinsmedicine.org/health/conditions-and-diseases/infectious-mononucleosis | access-date = 23 Sep 2020 | archive-date = 15 August 2020 | archive-url = https://web.archive.org/web/20200815055115/https://www.hopkinsmedicine.org/health/conditions-and-diseases/infectious-mononucleosis | url-status = live }}</ref> There may also be some [[Hepatomegaly|enlargement of the liver]].<ref name=Ebell2004/> [[Jaundice]] occurs only occasionally.<ref name=Harrison/><ref>{{cite journal|last1=Evans|first1=Alfred S.|title=Liver involvement in infectious mononucleosis|journal=Journal of Clinical Investigation|date=1 January 1948|volume=27|issue=1|pages=106–110|doi=10.1172/JCI101913|pmc=439479|pmid=16695521}}</ref> It generally gets better on its own in people who are otherwise healthy.<ref name="pmid29885408"/> When caused by EBV, infectious mononucleosis is classified as one of the [[Epstein–Barr virus–associated lymphoproliferative diseases]]. Occasionally the disease may persist and result in a chronic infection. This may develop into systemic EBV-positive T cell [[lymphoma]].<ref name="pmid29885408">{{cite journal | vauthors = Rezk SA, Zhao X, Weiss LM | title = Epstein-Barr virus (EBV)-associated lymphoid proliferations, a 2018 update | journal = Human Pathology | volume = 79 | pages = 18–41 | date = September 2018 | pmid = 29885408 | doi = 10.1016/j.humpath.2018.05.020 | s2cid = 47010934 }}</ref>
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