Editing Inclusion body myositis (section)

===Genetics===
sIBM is not inherited and is not passed on to the children of IBM patients. There are genetic features that do not directly cause IBM but that appear to predispose a person to getting IBM&nbsp;– having this particular combination of genes increases one's susceptibility to getting IBM. Some 67% of IBM patients have a particular combination of [[human leukocyte antigen]] genes in a section of the 8.1 ancestral haplotype in the center of the MHC class II region. sIBM is not passed on from generation to generation, although the susceptibility region of genes may be.<ref name="pmid16932602"/>

There are also several rare forms of hereditary inclusion body myopathy that are linked to specific genetic defects and that are passed on from generation to generation. Since these forms do not show features of muscle inflammation, they are classified as myopathies rather than forms of myositis. Because they do not display inflammation as a primary symptom, they may in fact be similar, but different diseases to sporadic inclusion body myositis. There are several different types, each inherited in different ways. See [[hereditary inclusion body myopathy]].<ref>{{Cite web |title=Inclusion body myopathy 2: MedlinePlus Genetics |url=https://medlineplus.gov/genetics/condition/inclusion-body-myopathy-2/ |access-date=2022-11-18 |website=medlineplus.gov |language=en}}</ref>

A 2007 review concluded there is no indication that the genes responsible for the familial or hereditary conditions are involved in sIBM.<ref name="pmid17366591">{{cite journal |vauthors=Needham M, Mastaglia FL, Garlepp MJ |title=Genetics of inclusion-body myositis |journal=Muscle Nerve |volume=35 |issue=5 |pages=549–561 |year=2007 |pmid=17366591 |doi=10.1002/mus.20766|s2cid=23665612 }}</ref>