Editing Febrile seizure (section)

== Mechanism ==
The exact underlying mechanism of febrile seizures is still unknown, but it is thought to be multi-factorial involving genetic and environmental factors.<ref name="Leu2018" /><ref name=BMJ2015 /> Speculation includes immaturity of the [[central nervous system]] at younger ages, making the brain more vulnerable to the effects of fever.<ref name="Leu2018" /><ref name=":2">{{cite journal|last1=Whelan|first1=Harry|last2=Harmelink|first2=Matthew|last3=Chou|first3=Erica|last4=Sallowm|first4=Delphin|last5=Khan|first5=Nadir|last6=Patil|first6=Rachit|last7=Sannagowdara|first7=Kumar|last8=Kim|first8=Jun Ho|last9=Chen|first9=Wei Liang|last10=Khalil|first10=Suad|last11=Bajic|first11=Ivana|date=2017|title=Complex febrile seizures—A systematic review|journal=Disease-a-Month|language=en|volume=63|issue=1|pages=5–23|doi=10.1016/j.disamonth.2016.12.001|pmid=28089358|doi-access=free}}</ref> The increased activity of [[neuron]]s during [[Development of the nervous system|rapid brain development]], may help explain why children, particularly younger than age 3, are prone to febrile seizures, with occurrences decreasing after age 5.<ref name=Leu2018/> Other proposed mechanisms include the interactions of [[Inflammation|inflammatory mediators]], particularly [[cytokine]]s, which are released during a fever, causing elevated temperatures in the brain, which may somehow lead to a seizure.<ref name=BMJ2015 /><ref name=Kwon2018>{{cite journal|last1=Kwon|first1=Aram|last2=Kwak|first2=Byung Ok|last3=Kim|first3=Kyungmin|last4=Ha|first4=Jongseok|last5=Kim|first5=Soo-Jin|last6=Bae|first6=Sun Hwan|last7=Son|first7=Jae Sung|last8=Kim|first8=Soo-Nyung|last9=Lee|first9=Ran|date=2018|title=Cytokine levels in febrile seizure patients: A systematic review and meta-analysis|journal=Seizure|language=en|volume=59|pages=5–10|doi=10.1016/j.seizure.2018.04.023|pmid=29727742|doi-access=free}}</ref> Specific cytokines implicated include elevated [[Cerebrospinal fluid|CSF]] [[Interleukin 1 beta|IL-1β]] and [[Serum (blood)|serum]] [[Interleukin 6|IL-6]].<ref name=Kwon2018 />