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=== Drug resistance === [[Antimicrobial resistance|Antibiotic resistance]] applies specifically to [[bacteria]] that become resistant to [[antibiotic]]s.<ref name="WHO2014">{{cite web |date=April 2014 |title=Antimicrobial resistance Fact sheet NΒ°194 |url=https://www.who.int/mediacentre/factsheets/fs194/en/ |url-status=live |archive-url=https://web.archive.org/web/20150310081111/http://www.who.int/mediacentre/factsheets/fs194/en/ |archive-date=10 March 2015 |access-date=7 March 2015 |website=who.int}}</ref> Resistance in bacteria can arise naturally by [[genetic mutation]], or by one species acquiring resistance from another through [[horizontal gene transfer]].<ref>{{Cite web |title=General Background: About Antibiotic Resistance |url=http://www.tufts.edu/med/apua/about_issue/about_antibioticres.shtml |url-status=dead |archive-url=https://web.archive.org/web/20151023035356/http://www.tufts.edu/med/apua/about_issue/about_antibioticres.shtml |archive-date=23 October 2015 |access-date=30 October 2015 |website=www.tufts.edu}}</ref> Extended use of antibiotics appears to encourage selection for mutations which can render antibiotics ineffective. This is especially true of [[tuberculosis]], with increasing occurrence of [[Multi-drug-resistant tuberculosis|multiple drug-resistant tuberculosis]] (MDR-TB) worldwide.<ref name="WHO2015Fact">{{Cite web |title=Tuberculosis (TB) |url=https://www.who.int/news-room/fact-sheets/detail/tuberculosis |url-status=live |archive-url=https://web.archive.org/web/20200730165218/https://www.who.int/news-room/fact-sheets/detail/tuberculosis |archive-date=30 July 2020 |access-date=8 May 2020 |website=who.int |language=en}}</ref><ref>{{cite journal |vauthors=Dabour R, Meirson T, Samson AO |date=December 2016 |title=Global antibiotic resistance is mostly periodic |journal=Journal of Global Antimicrobial Resistance |volume=7 |pages=132β134 |doi=10.1016/j.jgar.2016.09.003 |pmid=27788414}}</ref>
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