Editing Ephedrine (section)

==Contraindications==
Ephedrine should not be used in conjunction with certain [[Antidepressant|antidepressants]], namely [[Norepinephrine–dopamine reuptake inhibitor|norepinephrine–dopamine reuptake inhibitors]] (NDRIs), as this increases the risk of symptoms due to excessive serum levels of norepinephrine.{{Citation needed|date=March 2025}}

[[Bupropion]] is an example of an antidepressant with an amphetamine-like structure similar to ephedrine, and it is an NDRI. Its action bears more resemblance to amphetamine than to [[fluoxetine]] in that its primary mode of therapeutic action involves norepinephrine and to a lesser degree dopamine, but it also releases some [[serotonin]] from presynaptic clefts. It should not be used with ephedrine, as it may increase the likelihood of side effects.{{Citation needed|date=March 2025}}

Ephedrine should be used with caution in patients with inadequate fluid replacement, impaired adrenal function, [[Hypoxia (medical)|hypoxia]], [[hypercapnia]], [[acidosis]], [[hypertension]], [[hyperthyroidism]], [[prostatic hypertrophy]], [[diabetes mellitus]], [[cardiovascular]] disease, during delivery if maternal blood pressure is >130/80 mmHg, and during lactation.<ref name =Mayne>Mayne Pharma. Ephedrine sulfate injection DBL (Approved Product Information). Melbourne: Mayne Pharma; 2004</ref>

[[Contraindications]] for the use of ephedrine include: [[glaucoma|closed-angle glaucoma]], [[phaeochromocytoma]], [[Hypertrophic cardiomyopathy#Obstructive and non-obstructive|asymmetric septal hypertrophy]] (idiopathic hypertrophic subaortic stenosis), concomitant or recent (previous 14 days) [[monoamine oxidase inhibitor]] (MAOI) therapy, general [[anesthesia]] with halogenated hydrocarbons (particularly [[halothane]]), tachyarrhythmias or ventricular fibrillation, or hypersensitivity to ephedrine or other stimulants.{{citation needed|date=March 2023}}

Ephedrine should not be used at any time during pregnancy unless specifically indicated by a qualified physician and only when other options are unavailable.<ref name =Mayne />