Editing DNA sequencer (section)

===Illumina===
[[File:GA2.JPG|thumbnail|Illumina Genome Analyzer II sequencing machine]]
[[Illumina (company)|Illumina]] produces a number of next-generation sequencing machines using technology acquired from [[Manteia Predictive Medicine]] and developed by Solexa.<ref>{{cite news |last1=Marcial |first1=Gene G. |title=Solexa's Progress Is In The Genes |url=https://www.bloomberg.com/news/articles/2006-11-05/solexas-progress-is-in-the-genes |newspaper=Bloomberg |date=6 November 2006 |access-date=10 January 2022}}</ref> Illumina makes a number of next generation sequencing machines using this technology including the HiSeq, Genome Analyzer IIx, MiSeq and the HiScanSQ, which can also process [[DNA microarray|microarrays]].<ref>{{Cite web|url=https://www.illumina.com/systems.html|title=Sequencing and Microarray Systems|website=www.illumina.com}}</ref>

The technology leading to these DNA sequencers was first released by Solexa in 2006 as the Genome Analyzer.<ref name="Comparison Next-Gen Seq" /> Illumina purchased Solexa in 2007. The Genome Analyzer uses a sequencing by synthesis method. The first model produced 1G per run. During the year 2009 the output was increased from 20G per run in August to 50G per run in December. In 2010 Illumina released the HiSeq 2000 with an output of 200 and then 600G per run which would take 8 days. At its release the HiSeq 2000 provided one of the cheapest sequencing platforms at $0.02 per million bases as costed by the [[Beijing Genomics Institute]].

In 2011 Illumina released a benchtop sequencer called the MiSeq. At its release the MiSeq could generate 1.5G per run with paired end 150bp reads. A sequencing run can be performed in 10 hours when using automated DNA sample preparation.<ref name="Comparison Next-Gen Seq" />

The Illumina HiSeq uses two software tools to calculate the number and position of DNA clusters to assess the sequencing quality: the HiSeq control system and the real-time analyzer. These methods help to assess if nearby clusters are interfering with each other.<ref name="Comparison Next-Gen Seq" />