Editing Chelation (section)

=== Animal feed additives ===
Synthetic chelates such as [[ethylenediaminetetraacetic acid]] (EDTA) proved too stable and not nutritionally viable. If the mineral was taken from the EDTA ligand, the ligand could not be used by the body and would be expelled. During the expulsion process, the EDTA ligand randomly chelated and stripped other minerals from the body.<ref>{{cite book |last=Ashmead |first=H. DeWayne |name-list-style=vanc |title=The Roles of Amino Acid Chelates in Animal Nutrition |year=1993 |publisher=Noyes Publications |location=Westwood|isbn=0815513127}}{{page needed|date=December 2015}}</ref> According to the Association of American Feed Control Officials (AAFCO), a metal–amino acid chelate is defined as the product resulting from the reaction of metal ions from a soluble metal salt with amino acids, with a [[mole ratio]] in the range of 1–3 (preferably 2) moles of amino acids for one mole of metal.{{Citation needed|date=October 2018}} The average weight of the hydrolyzed amino acids must be approximately 150 and the resulting molecular weight of the chelate must not exceed 800&nbsp;[[Dalton (unit)|Da]].{{citation needed|date=December 2015}} Since the early development of these compounds, much more research has been conducted, and has been applied to human nutrition products in a similar manner to the animal nutrition experiments that pioneered the technology. [[Iron supplement|Ferrous bis-glycinate]] is an example of one of these compounds that has been developed for human nutrition.<ref>{{cite web |publisher=Albion Laboratories, Inc. |title=Albion Ferrochel Website |url=http://www.albionferrochel.com/ |access-date=July 12, 2011 |archive-date=September 3, 2011 |archive-url=https://web.archive.org/web/20110903054502/http://www.albionferrochel.com/ |url-status=dead}}</ref>