Editing Calreticulin (section)

== Role in cancer ==

Calreticulin (CRT) is expressed in many cancer cells and plays a role to promote [[macrophage]]s to engulf hazardous cancerous cells. The reason why most of the cells are not destroyed is the presence of another molecule with signal [[CD47]], which blocks CRT.  Hence antibodies that block CD47 might be useful as a cancer treatment. In mice models of [[myeloid leukemia]] and [[non-Hodgkin lymphoma]], anti-CD47 were effective in clearing cancer cells while normal cells were unaffected.<ref name="pmid21178137">{{cite journal | vauthors = Chao MP, Jaiswal S, Weissman-Tsukamoto R, Alizadeh AA, Gentles AJ, Volkmer J, Weiskopf K, Willingham SB, Raveh T, Park CY, Majeti R, Weissman IL | title = Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47 | journal = Science Translational Medicine | volume = 2 | issue = 63 | pages = 63ra94 | date = Dec 2010 | pmid = 21178137 | pmc = 4126904 | doi = 10.1126/scitranslmed.3001375}}
*{{cite web |author=Christopher Vaughan |date=December 22, 2010 |title=Many cancer cells found to have an 'eat me' signal in study |website=Stanford School of Medicine |url=http://med.stanford.edu/ism/2010/december/crt-signal.html |archive-url=https://web.archive.org/web/20131016145928/http://med.stanford.edu/ism/2010/december/crt-signal.html |archive-date=2013-10-16}}</ref>