Editing Base pair (section)

==Mismatch repair==

Mismatched base pairs can be generated by errors of [[DNA replication]] and as intermediates during [[homologous recombination]]. The process of mismatch repair ordinarily must recognize and correctly repair a small number of base mispairs within a long sequence of normal DNA base pairs.  To repair mismatches formed during DNA replication, several distinctive repair processes have evolved to distinguish between the template strand and the newly formed strand so that only the newly inserted incorrect nucleotide is removed (in order to avoid generating a mutation).<ref>{{cite journal | vauthors = Putnam CD | title = Strand discrimination in DNA mismatch repair | journal = DNA Repair | volume = 105 | pages = 103161 | date = September 2021 | pmid = 34171627 | pmc = 8785607 | doi = 10.1016/j.dnarep.2021.103161 }}</ref>  The proteins employed in mismatch repair during DNA replication, and the clinical significance of defects in this process are described in the article [[DNA mismatch repair]].  The process of mispair correction during recombination is described in the article [[gene conversion]].