Editing Asphyxia (section)

===Perinatal asphyxia===
{{Main|Perinatal asphyxia}}

Perinatal asphyxia is the medical condition resulting from deprivation of [[oxygen]] ([[Hypoxia (medical)|hypoxia]]) to a newborn infant long enough to cause apparent harm. It results most commonly from a drop in maternal [[blood pressure]] or interference during [[childbirth|delivery]] with blood flow to the infant's [[brain]]. This can occur as a result of inadequate [[circulatory system|circulation]] or [[perfusion]], impaired respiratory effort, or inadequate [[Ventilation (physiology)|ventilation]].<ref name="Davis" /> There has long been a scientific debate over whether [[Neonatal resuscitation|newborn infants with asphyxia should be resuscitated]] with 100% oxygen or normal air.<ref name="Davis">{{cite journal | vauthors = Davis PG, Tan A, O'Donnell CP, Schulze A | title = Resuscitation of newborn infants with 100% oxygen or air: a systematic review and meta-analysis | journal = Lancet | volume = 364 | issue = 9442 | pages = 1329–33 | year = 2004 | pmid = 15474135 | doi = 10.1016/S0140-6736(04)17189-4 | s2cid = 24825982 }}</ref> It has been demonstrated that high concentrations of oxygen lead to generation of oxygen [[free radicals]], which have a role in [[reperfusion injury]] after asphyxia.<ref>{{cite journal | vauthors = Kutzsche S, Ilves P, Kirkeby OJ, Saugstad OD | title = Hydrogen peroxide production in leukocytes during cerebral hypoxia and reoxygenation with 100% or 21% oxygen in newborn piglets | journal = Pediatric Research | volume = 49 | issue = 6 | pages = 834–42 | date = June 2001 | pmid = 11385146 | doi = 10.1203/00006450-200106000-00020 | doi-access = free | author-link4 = Ola Didrik Saugstad }}</ref> Research by [[Ola Didrik Saugstad]] and others led to new international guidelines on newborn resuscitation in 2010, recommending the use of normal air instead of 100% oxygen.<ref>ILCOR [[Neonatal resuscitation]] Guidelines 2010</ref><ref>{{cite web | url = http://www.norway.gr/News_and_events/Events/Older-articles/Norwegian-paediatrician-honoured-by-University-of-Athens-/ | title = Norwegian paediatrician honoured by University of Athens | archive-url = https://web.archive.org/web/20160304101405if_/http://www.norway.gr/News_and_events/Events/Older-articles/Norwegian-paediatrician-honoured-by-University-of-Athens-/#.Vtlf8C2l1qs | archive-date = 4 March 2016 | work = Royal Norwegian Embassy in Athens }}</ref>