Editing Aspartame (section)

===Metabolism and body weight===
{{as of|2017|post=,}} reviews of [[clinical trial]]s showed that using aspartame (or other non-nutritive sweeteners) in place of sugar reduces calorie intake and body weight in adults and children.<ref name=Az2017>{{cite journal | vauthors = Azad MB, Abou-Setta AM, Chauhan BF, Rabbani R, Lys J, Copstein L, Mann A, Jeyaraman MM, Reid AE, Fiander M, MacKay DS, McGavock J, Wicklow B, Zarychanski R | title = Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies | journal = CMAJ | volume = 189 | issue = 28 | pages = E929–E939 | date = July 2017 | pmid = 28716847 | pmc = 5515645 | doi = 10.1503/cmaj.161390 }}</ref><ref name="Rogers2016">{{cite journal | vauthors = Rogers PJ, Hogenkamp PS, de Graaf C, Higgs S, Lluch A, Ness AR, Penfold C, Perry R, Putz P, Yeomans MR, Mela DJ | title = Does low-energy sweetener consumption affect energy intake and body weight? A systematic review, including meta-analyses, of the evidence from human and animal studies | journal = International Journal of Obesity | volume = 40 | issue = 3 | pages = 381–394 | date = March 2016 | pmid = 26365102 | pmc = 4786736 | doi = 10.1038/ijo.2015.177 }}</ref><ref name="Miller2014">{{cite journal | vauthors = Miller PE, Perez V | title = Low-calorie sweeteners and body weight and composition: a meta-analysis of randomized controlled trials and prospective cohort studies | journal = The American Journal of Clinical Nutrition | volume = 100 | issue = 3 | pages = 765–777 | date = September 2014 | pmid = 24944060 | pmc = 4135487 | doi = 10.3945/ajcn.113.082826 }}</ref> A 2017 review of [[metabolism|metabolic effects]] by consuming aspartame found that it did not affect [[blood glucose]], [[insulin]], [[total cholesterol]], [[triglyceride]]s, calorie intake, or body weight. While [[high-density lipoprotein]] levels were higher compared to control, they were lower compared to sucrose.<ref name=San2017>{{cite journal | vauthors = Santos NC, de Araujo LM, De Luca Canto G, Guerra EN, Coelho MS, Borin MF | title = Metabolic effects of aspartame in adulthood: A systematic review and meta-analysis of randomized clinical trials | journal = Critical Reviews in Food Science and Nutrition | volume = 58 | issue = 12 | pages = 2068–2081 | date = April 2017 | pmid = 28394643 | doi = 10.1080/10408398.2017.1304358 | s2cid = 43863824 }}</ref>

In 2023, the [[World Health Organization]] recommended against the use of common non-sugar sweeteners (NSS), including aspartame, to control body weight or lower the risk of [[non-communicable disease]]s, stating: "The recommendation is based on the findings of a systematic review of the available evidence which suggests that use of NSS does not confer any long-term benefit in reducing body fat in adults or children. Results of the review also suggest that there may be potential undesirable effects from long-term use of NSS, such as an increased risk of type 2 diabetes, cardiovascular diseases, and mortality in adults."<ref>{{cite press release | title = WHO advises not to use non-sugar sweeteners for weight control in newly released guideline | date = 15 May 2023 | publisher = [[World Health Organization]] (WHO) | url = https://www.who.int/news/item/15-05-2023-who-advises-not-to-use-non-sugar-sweeteners-for-weight-control-in-newly-released-guideline | access-date = 30 June 2023 | archive-date = 30 June 2023 | archive-url = https://web.archive.org/web/20230630105256/https://www.who.int/news/item/15-05-2023-who-advises-not-to-use-non-sugar-sweeteners-for-weight-control-in-newly-released-guideline | url-status = live }}</ref><ref>{{cite tech report | title=Use of non-sugar sweeteners: WHO guideline | publisher=[[World Health Organization]] (WHO) | location=Geneva | date=15 May 2023 | url=https://www.who.int/publications/i/item/9789240073616 | isbn=978-92-4-007361-6 | hdl=10665/367660 | hdl-access=free }}</ref>