Editing Anaphase (section)

== Relation to the cell cycle ==
Anaphase accounts for approximately 1% of the [[cell cycle]]'s duration.<ref>{{cite journal | vauthors = Heath IB, Rethoret K | title = Temporal analysis of the nuclear cycle by serial section electron microscopy of the fungus, Saprolegnia ferax | journal = European Journal of Cell Biology | volume = 21 | issue = 2 | pages = 208–13 | date = June 1980 | pmid = 7398661 }}</ref> It begins with the regulated triggering of the metaphase-to-anaphase transition. [[Metaphase]] ends with the destruction of B [[cyclin]]. B cyclin is marked with [[ubiquitin]] which flags it for destruction by [[proteasomes]], which is required for the function of metaphase cyclin-dependent kinases (M-Cdks). In essence, Activation of the [[Anaphase-promoting complex]] (APC) causes the APC to cleave the M-phase cyclin and the inhibitory protein [[securin]] which activates the separase protease to cleave the [[cohesin]] subunits holding the [[chromatids]] together.