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=== Wound antisepsis === During [[World War I]] (1914–1918), Carrel and the English chemist [[Henry Drysdale Dakin]] developed the [[Carrel–Dakin method]] of treating wounds with an antiseptic solution based on chlorine, known as Dakin's solution. This method, which involved wound debridement and irrigation with a high volume of antiseptic fluid, was a significant medical advancement in the absence of antibiotics. For his contributions, Carrel was awarded the [[Legion of Honour|Légion d'honneur]]. The Carrel–Dakin method became widely used in hospitals. The mechanical irrigation technique developed by Carrel is still used today.<ref name=dakin1>Henry D. Dakin (1915): "On the use of certain antiseptic substances in the treatment of infected wounds". ''British Medical Journal'', volume 2, issue 2852, pp. 318–310.</ref><ref name=dakin2>H. D. Dakin and E. K. Kunham (1918). ''A Handbook of Antiseptics''. Published by Macmillan, New York.</ref><ref name=dakin3>H. D. Dakin (1915): ''Comptes rendues de la Academie des Sciences'', CLXI, p. 150. Cited by Marcel Dufresne, ''Presse médicale'' (1916)</ref>[[File:Medical Department - Hospitals - Rockefeller Hospital, New York City - On the Rockefeller lawn, sixty-fourth street and Avenue A - NARA - 45495210.jpg|thumb|Photograph of a ward of the Rockefeller War Demonstration Hospital.]]
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