Editing Aspirin (section)

=== Interactions ===
Aspirin is known to [[drug interaction|interact]] with other drugs. For example, [[acetazolamide]] and [[ammonium chloride]] are known to enhance the intoxicating effect of salicylates, and alcohol also increases the gastrointestinal bleeding associated with these types of drugs.<ref name="drugs.com">{{cite web |url=https://www.drugs.com/aspirin.html |title=Aspirin information from Drugs.com |publisher=Drugs.com |access-date=8 May 2008 |url-status=live |archive-url=https://web.archive.org/web/20080509163105/http://www.drugs.com/aspirin.html |archive-date=9 May 2008}}</ref><ref name="personalmd"/> Aspirin is known to displace a number of drugs from protein-binding sites in the blood, including the [[antidiabetic drug]]s [[tolbutamide]] and [[chlorpropamide]], [[warfarin]], [[methotrexate]], [[phenytoin]], [[probenecid]], [[valproic acid]] (as well as interfering with [[beta oxidation]], an important part of valproate metabolism), and other NSAIDs. Corticosteroids may also reduce the concentration of aspirin. Other NSAIDs, such as ibuprofen and naproxen, may reduce the antiplatelet effect of aspirin.<ref name="Alqahtani_2018">{{cite journal | vauthors = Alqahtani Z, Jamali F | title = Clinical Outcomes of Aspirin Interaction with Other Non-Steroidal Anti-Inflammatory Drugs: A Systematic Review | journal = Journal of Pharmacy & Pharmaceutical Sciences | volume = 21 | issue = 1s | pages = 48s–73s | date = 2018 | pmid = 29891025 | doi = 10.18433/jpps29854 | s2cid = 48361086 | doi-access = free }}</ref><ref name="Gladding_2008">{{cite journal | vauthors = Gladding PA, Webster MW, Farrell HB, Zeng IS, Park R, Ruijne N | title = The antiplatelet effect of six non-steroidal anti-inflammatory drugs and their pharmacodynamic interaction with aspirin in healthy volunteers | journal = The American Journal of Cardiology | volume = 101 | issue = 7 | pages = 1060–1063 | date = April 2008 | pmid = 18359332 | doi = 10.1016/j.amjcard.2007.11.054 }}</ref> Although limited evidence suggests this may not result in a reduced cardioprotective effect of aspirin.<ref name="Alqahtani_2018" /> Analgesic doses of aspirin decrease sodium loss induced by spironolactone in the urine, however this does not reduce the antihypertensive effects of spironolactone.<ref>{{cite web | veditors = Baxter K, Preston CL | work = MedicinesComplete: Stockley's Drug Interactions. | location = | publisher = Royal Pharmaceutical Society |title=Aspirin and Spironolactone |url=https://www.medicinescomplete.com}}</ref> Furthermore, antiplatelet doses of aspirin are deemed too small to produce an interaction with spironolactone.<ref>{{cite journal | vauthors = Hollifield JW |title=Failure of aspirin to antagonize the antihypertensive effect of spironolactone in low-renin hypertension. |journal=Southern Medical Journal |date=August 1976 |volume=69 |issue=8 |pages=1034–6 |doi=10.1097/00007611-197608000-00022 |pmid=785608 }}</ref> Aspirin is known to compete with [[penicillin|penicillin G]] for renal tubular secretion.<ref name="interactions">{{cite book |vauthors=Katzung BG |year=1998 |title=Basic and clinical pharmacology |url=https://archive.org/details/basicclinicalph100katz/page/584 |publisher=McGraw-Hill |page=584 |isbn=978-0-8385-0565-6}}</ref> Aspirin may also inhibit the absorption of vitamin C.<ref>{{cite journal | vauthors = Loh HS, Watters K, Wilson CW | title = The effects of aspirin on the metabolic availability of ascorbic acid in human beings | journal = Journal of Clinical Pharmacology | volume = 13 | issue = 11 | pages = 480–486 | date = 1 November 1973 | pmid = 4490672 | doi = 10.1002/j.1552-4604.1973.tb00203.x }}</ref><ref>{{cite journal | vauthors = Basu TK | title = Vitamin C-aspirin interactions | journal = International Journal for Vitamin and Nutrition Research. Supplement | volume = 23 | pages = 83–90 | year = 1982 | pmid = 6811490 }}</ref>{{Unreliable medical source|date=August 2016}}<ref>{{cite journal | vauthors = Ioannides C, Stone AN, Breacker PJ, Basu TK | title = Impairment of absorption of ascorbic acid following ingestion of aspirin in guinea pigs | journal = Biochemical Pharmacology | volume = 31 | issue = 24 | pages = 4035–4038 | date = December 1982 | pmid = 6818974 | doi = 10.1016/0006-2952(82)90652-9 }}</ref>