Editing Aspirin (section)

===Overdose===
{{Main|Aspirin poisoning}}
[[File:Symptoms of aspirin overdose.svg|thumb|Symptoms of aspirin overdose]]

Aspirin overdose can be acute or chronic. In acute poisoning, a single large dose is taken; in chronic poisoning, higher than normal doses are taken over a period of time. Acute overdose has a [[mortality rate]] of 2%. Chronic overdose is more commonly lethal, with a mortality rate of 25%;<ref>{{cite web |vauthors = Kreplick LW |year=2001 |title=Salicylate toxicity in emergency medicine |publisher=[[Medscape]] |url=http://misc.medscape.com/pi/android/medscapeapp/html/A818242-business.html |url-status=live |archive-url=https://web.archive.org/web/20120831184805/http://misc.medscape.com/pi/android/medscapeapp/html/A818242-business.html |archive-date=31 August 2012}}</ref> chronic overdose may be especially severe in children.<ref name="Pediatrics1982-gaudreault">{{cite journal |vauthors = Gaudreault P, Temple AR, Lovejoy FH |title = The relative severity of acute versus chronic salicylate poisoning in children: a clinical comparison |journal = Pediatrics |volume = 70 |issue = 4 |pages = 566–9 |date = October 1982 |doi = 10.1542/peds.70.4.566 |pmid = 7122154 |s2cid = 12738659 }} (primary source)</ref> Toxicity is managed with a number of potential treatments, including [[activated charcoal]], intravenous dextrose and normal saline, [[sodium bicarbonate]], and [[Kidney dialysis|dialysis]].<ref>{{cite book |title=Rosen's emergency medicine: concepts and clinical practice |vauthors = Marx J |year=2006 |publisher=Mosby/Elsevier |isbn=978-0-323-02845-5 |page=2242 |url=https://archive.org/details/rosensemergencym0002unse/page/2242 }}</ref> The diagnosis of poisoning usually involves measurement of plasma salicylate, the active metabolite of aspirin, by automated spectrophotometric methods. Plasma salicylate levels in general range from 30 to 100{{nbsp}}mg/L after usual therapeutic doses, 50–300{{nbsp}}mg/L in people taking high doses and 700–1400{{nbsp}}mg/L following acute overdose. Salicylate is also produced as a result of exposure to [[bismuth subsalicylate]], [[methyl salicylate]], and [[sodium salicylate]].<ref>{{cite journal |vauthors = Morra P, Bartle WR, Walker SE, Lee SN, Bowles SK, Reeves RA |title = Serum concentrations of salicylic acid following topically applied salicylate derivatives |journal = The Annals of Pharmacotherapy |volume = 30 |issue = 9 |pages = 935–40 |date = September 1996 |pmid = 8876850 |doi = 10.1177/106002809603000903 |s2cid = 9843820 }}</ref><ref>{{cite book |vauthors = Baselt R |title=Disposition of toxic drugs and chemicals in man |edition=9th |publisher=Biomedical Publications |location=Seal Beach, California |year=2011 |pages=20–23|isbn=978-0-9626523-8-7 }}</ref>