Editing Life extension (section)

===Lifestyle factors===
{{See also|Lifestyle disease}}
[[Loneliness]]/isolation, social life and support,<ref name="niha"/><ref>{{cite journal | vauthors = Vila J | title = Social Support and Longevity: Meta-Analysis-Based Evidence and Psychobiological Mechanisms | journal = Frontiers in Psychology | volume = 12 | pages = 717164 | date = 2021 | pmid = 34589025 | pmc = 8473615 | doi = 10.3389/fpsyg.2021.717164 | doi-access = free }}</ref> exercise/physical activity (partly via [[neurobiological effects of physical exercise|neurobiological effects]] and increased NAD+ levels),<ref name="niha">{{cite web |title=What Do We Know About Healthy Aging? |date=23 February 2022 |url=https://www.nia.nih.gov/health/what-do-we-know-about-healthy-aging |publisher=[[National Institute on Aging]] |access-date=1 June 2022 |language=en}}</ref><ref>{{cite journal | vauthors = O'Keefe EL, Torres-Acosta N, O'Keefe JH, Lavie CJ | title = Training for Longevity: The Reverse J-Curve for Exercise | journal = Missouri Medicine | volume = 117 | issue = 4 | pages = 355–361 | date = July 2020 | pmid = 32848273 | pmc = 7431070 | quote = Current studies suggest that 2.5 to 5 hours/week of moderate or vigorous physical activity will confer maximal benefits; >10 hours/week may reduce these health benefits. }}</ref><ref name="Campisi-2019"/><ref name="Lopez-Otin-2016"/><ref>{{cite journal | vauthors = Min S, Masanovic B, Bu T, Matic RM, Vasiljevic I, Vukotic M, Li J, Vukovic J, Fu T, Jabucanin B, Bujkovic R, Popovic S | display-authors = 6 | title = The Association Between Regular Physical Exercise, Sleep Patterns, Fasting, and Autophagy for Healthy Longevity and Well-Being: A Narrative Review | journal = Frontiers in Psychology | volume = 12 | pages = 803421 | date = 2 December 2021 | pmid = 34925198 | pmc = 8674197 | doi = 10.3389/fpsyg.2021.803421 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Hofer SJ, Davinelli S, Bergmann M, Scapagnini G, Madeo F | title = Caloric Restriction Mimetics in Nutrition and Clinical Trials | journal = Frontiers in Nutrition | volume = 8 | pages = 717343 | date = 2021 | pmid = 34552954 | doi = 10.3389/fnut.2021.717343 | pmc = 8450594 | doi-access = free }}</ref> psychological characteristics/personality (possibly highly indirectly),<ref>{{cite journal | vauthors = Chapman BP, Roberts B, Duberstein P | title = Personality and longevity: knowns, unknowns, and implications for public health and personalized medicine | journal = Journal of Aging Research | volume = 2011 | pages = 759170 | date = 10 July 2011 | pmid = 21766032 | doi = 10.4061/2011/759170 | pmc = 3134197 | s2cid = 16615606 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Kern ML, Friedman HS | title = Do conscientious individuals live longer? A quantitative review | journal = Health Psychology | volume = 27 | issue = 5 | pages = 505–512 | date = September 2008 | pmid = 18823176 | doi = 10.1037/0278-6133.27.5.505 }}</ref> sleep duration,<ref name="niha"/> [[circadian rhythm]]s (patterns of sleep, drug-administration and feeding),<ref>{{cite journal | vauthors = Froy O, Miskin R | title = Effect of feeding regimens on circadian rhythms: implications for aging and longevity | journal = Aging | volume = 2 | issue = 1 | pages = 7–27 | date = December 2010 | pmid = 20228939 | pmc = 2837202 | doi = 10.18632/aging.100116 }}</ref><ref>{{cite journal | vauthors = Froy O | title = Circadian rhythms, aging, and life span in mammals | journal = Physiology | volume = 26 | issue = 4 | pages = 225–235 | date = August 2011 | pmid = 21841071 | doi = 10.1152/physiol.00012.2011 }}</ref><ref>{{cite journal | vauthors = Acosta-Rodríguez VA, Rijo-Ferreira F, Green CB, Takahashi JS | title = Importance of circadian timing for aging and longevity | journal = Nature Communications | volume = 12 | issue = 1 | pages = 2862 | date = May 2021 | pmid = 34001884 | doi = 10.1038/s41467-021-22922-6 | pmc = 8129076 | bibcode = 2021NatCo..12.2862A | s2cid = 234770669 }}</ref> type of leisure activities,<ref name="niha"/> not smoking,<ref name="niha"/> altruistic emotions and behaviors,<ref>{{cite journal | vauthors = Post SG | title = Altuism, happiness, and health: it's good to be good | journal = International Journal of Behavioral Medicine | volume = 12 | issue = 2 | pages = 66–77 | date = 2005 | pmid = 15901215 | doi = 10.1207/s15327558ijbm1202_4 | s2cid = 12544814 }}</ref><ref>{{cite journal | vauthors = Gottlieb BH, Gillespie AA | title = Volunteerism, health, and civic engagement among older adults | journal = Canadian Journal on Aging | volume = 27 | issue = 4 | pages = 399–406 | date = 2008 | pmid = 19416800 | doi = 10.3138/cja.27.4.399 | s2cid = 24698644 }}</ref> subjective [[well-being]],<ref>{{cite journal | vauthors = Diener E, Oishi S, Tay L | title = Advances in subjective well-being research | journal = Nature Human Behaviour | volume = 2 | issue = 4 | pages = 253–260 | date = April 2018 | pmid = 30936533 | doi = 10.1038/s41562-018-0307-6 | s2cid = 4726262 }}</ref> mood<ref name="niha"/> and stress (including via [[heat shock protein]])<ref name="niha"/><ref>{{cite journal | vauthors = Gomez CR | title = Role of heat shock proteins in aging and chronic inflammatory diseases | journal = GeroScience | volume = 43 | issue = 5 | pages = 2515–2532 | date = October 2021 | pmid = 34241808 | pmc = 8599533 | doi = 10.1007/s11357-021-00394-2 }}</ref> are investigated as potential (modulatable) factors of life extension.

Healthy lifestyle practices and healthy diet have been suggested as "first-line function-preserving strategies, with pharmacological agents, including existing and new pharmaceuticals and novel 'nutraceutical' compounds, serving as potential complementary approaches".<ref>{{cite journal | vauthors = Seals DR, Justice JN, LaRocca TJ | title = Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity | journal = The Journal of Physiology | volume = 594 | issue = 8 | pages = 2001–2024 | date = April 2016 | pmid = 25639909 | doi = 10.1113/jphysiol.2014.282665 | pmc = 4933122 | s2cid = 9776021 }}</ref>