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===Comparison of effects of brimonidine and timolol=== A 2013 [[Cochrane Collaboration|Cochrane systematic review]] compared the effect of brimonidine and timolol in slowing the progression of open angle glaucoma in adult participants.<ref name="Sena">{{cite journal | vauthors = Sena DF, Lindsley K | title = Neuroprotection for treatment of glaucoma in adults | journal = The Cochrane Database of Systematic Reviews | volume = 1 | pages = CD006539 | date = January 2017 | issue = 1 | pmid = 28122126 | pmc = 5370094 | doi = 10.1002/14651858.CD006539.pub4 }}</ref> The results showed that participants assigned to brimonidine showed less visual field progression than those assigned to timolol, though the results were not significant, given the heavy [[Lost to follow-up|loss-to-followup]] and limited evidence.<ref name=Sena/> The mean intraocular pressures for both groups were similar. Participants in the brimonidine group had a higher occurrence of side effects caused by medication than participants in the timolol group.<ref name=Sena/>
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