Editing Aspirin (section)

===Skin===
For a small number of people, taking aspirin can result in symptoms including [[hives]], swelling, and headache.<ref>{{cite web |url=https://health.clevelandclinic.org/are-you-sensitive-to-aspirin-here-are-some-reasons-why/ |title=Are You Sensitive to Aspirin? Here are Some Reasons Why |date=5 February 2015 |website=Health Essentials from Cleveland Clinic |access-date=5 March 2020 |archive-date=25 October 2020 |archive-url=https://web.archive.org/web/20201025171549/https://health.clevelandclinic.org/are-you-sensitive-to-aspirin-here-are-some-reasons-why/ |url-status=dead }}</ref> Aspirin can exacerbate symptoms among those with chronic hives, or create acute symptoms of hives.<ref name="Doña-2018">{{cite journal |vauthors = Doña I, Barrionuevo E, Salas M, Laguna JJ, Agúndez J, García-Martín E, Bogas G, Perkins JR, Cornejo-García JA, Torres MJ |title = NSAIDs-hypersensitivity often induces a blended reaction pattern involving multiple organs |journal = Scientific Reports |volume = 8 |issue = 1 |pages = 16710 |date = November 2018 |pmid = 30420763 |pmc = 6232098 |doi = 10.1038/s41598-018-34668-1 |bibcode = 2018NatSR...816710D }}</ref> These responses can be due to allergic reactions to aspirin, or more often due to its effect of inhibiting the COX-1 enzyme.<ref name="Doña-2018" /><ref name="Kowalski-2019">{{cite journal |vauthors = Kowalski ML, Agache I, Bavbek S, Bakirtas A, Blanca M, Bochenek G, Bonini M, Heffler E, Klimek L, Laidlaw TM, Mullol J, Niżankowska-Mogilnicka E, Park HS, Sanak M, Sanchez-Borges M, Sanchez-Garcia S, Scadding G, Taniguchi M, Torres MJ, White AA, Wardzyńska A |title = Diagnosis and management of NSAID-Exacerbated Respiratory Disease (N-ERD)-a EAACI position paper |journal = Allergy |volume = 74 |issue = 1 |pages = 28–39 |date = January 2019 |pmid = 30216468 |doi = 10.1111/all.13599 |s2cid = 52276808 |doi-access = free | title-link = doi }}</ref> Skin reactions may also tie to systemic contraindications, seen with NSAID-precipitated [[bronchospasm]],<ref name="Doña-2018" /><ref name="Kowalski-2019" /> or those with [[atopy]].<ref>{{cite journal |vauthors = Sánchez-Borges M, Capriles-Hulett A |title = Atopy is a risk factor for non-steroidal anti-inflammatory drug sensitivity |journal = Annals of Allergy, Asthma & Immunology |volume = 84 |issue = 1 |pages = 101–6 |date = January 2000 |pmid = 10674573 |doi = 10.1016/S1081-1206(10)62748-2 }}</ref>

Aspirin and other NSAIDs, such as ibuprofen, may delay the healing of skin wounds.<ref>{{cite journal |vauthors=Stadelmann WK, Digenis AG, Tobin GR |title=Impediments to wound healing |journal=American Journal of Surgery |volume=176 |issue=2A Suppl |pages=39S–47S |date=August 1998 |pmid=9777971 |doi=10.1016/S0002-9610(98)00184-6}}</ref> Earlier findings from two small, low-quality trials suggested a benefit with aspirin (alongside compression therapy) on venous leg ulcer healing time and leg ulcer size,<ref>{{cite journal |vauthors=Layton AM, Ibbotson SH, Davies JA, Goodfield MJ |title=Randomised trial of oral aspirin for chronic venous leg ulcers |journal=Lancet |volume=344 |issue=8916 |pages=164–5 |date=July 1994 |pmid=7912767 |doi=10.1016/s0140-6736(94)92759-6 |s2cid=912169}}</ref><ref>{{cite journal |vauthors=del Río Solá ML, Antonio J, Fajardo G, Vaquero Puerta C |title=Influence of aspirin therapy in the ulcer associated with chronic venous insufficiency |journal=Annals of Vascular Surgery |volume=26 |issue=5 |pages=620–9 |date=July 2012 |pmid=22437068 |doi=10.1016/j.avsg.2011.02.051 | hdl=10324/2904 |hdl-access=free }}</ref><ref>{{cite journal |vauthors=de Oliveira Carvalho PE, Magolbo NG, De Aquino RF, Weller CD |title=Oral aspirin for treating venous leg ulcers |journal=The Cochrane Database of Systematic Reviews |volume=2016 |pages=CD009432 |date=February 2016 |issue=2 |pmid=26889740 |doi=10.1002/14651858.CD009432.pub2 |pmc=8627253 |collaboration=Cochrane Wounds Group}}</ref> however, larger, more recent studies of higher quality have been unable to corroborate these outcomes.<ref>{{cite journal |vauthors=Jull A, Wadham A, Bullen C, Parag V, Kerse N, Waters J |title=Low dose aspirin as adjuvant treatment for venous leg ulceration: pragmatic, randomised, double blind, placebo controlled trial (Aspirin4VLU) |journal=BMJ |volume=359 |pages=j5157 |date=November 2017 |pmid=29175902 |pmc=5701114 |doi=10.1136/bmj.j5157}}</ref><ref>{{cite journal|vauthors=Tilbrook H, Clark L, Cook L, Bland M, Buckley H, Chetter I, Dumville J, Fenner C, Forsythe R, Gabe R, Harding K, Layton A, Lindsay E, McDaid C, Moffatt C, Rolfe D, Sbizzera I, Stansby G, Torgerson D, Vowden P, Williams L, Hinchliffe R|date=October 2018|title=AVURT: aspirin versus placebo for the treatment of venous leg ulcers - a Phase II pilot randomised controlled trial|journal=Health Technology Assessment|volume=22|issue=55|pages=1–138|doi=10.3310/hta22550|pmc=6204573|pmid=30325305}}</ref>