Editing Zebrafish (section)

===Computational data analysis===
Using smart data analysis methods, pathophysiological and pharmacological processes can be understood and subsequently translated to higher vertebrates, including humans.<ref name = vanwijk2016/><ref name = schulthess2018>{{cite journal |vauthors=Schulthess P, van Wijk RC, Krekels EH, Yates JW, Spaink HP, van der Graaf PH |title=Outside-In Systems Pharmacology Combines Innovative Computational Methods With High-Throughput Whole Vertebrate Studies |journal=CPT: Pharmacometrics & Systems Pharmacology |volume=7 |issue=5 |pages=285–287 |date=May 2018 |pmid=29693322 |pmc=5980533 |doi=10.1002/psp4.12297 |name-list-style=vanc}}</ref> An example is the use of [[systems pharmacology]], which is the integration of [[systems biology]] and [[pharmacometrics]]. 
Systems biology characterizes (part of) an organism by a mathematical description of all relevant processes. These can be for example different signal transduction pathways that upon a specific signal lead to a certain response. By quantifying these processes, their behaviour in healthy and diseased situation can be understood and predicted. 
Pharmacometrics uses data from preclinical experiments and [[clinical trials]] to characterize the pharmacological processes that are underlying the relation between the drug dose and its response or clinical outcome. These can be for example the drug [[absorption (pharmacology)|absorption]] in or [[clearance (pharmacology)|clearance]] from the body, or its interaction with the target to achieve a certain effect. By quantifying these processes, their behaviour after different doses or in different patients can be understood and predicted to new doses or patients.
By integrating these two fields, systems pharmacology has the potential to improve the understanding of the interaction of the drug with the biological system by mathematical quantification and subsequent prediction to new situations, like new drugs or new organisms or patients.
Using these computational methods, the previously mentioned analysis of paracetamol internal exposure in zebrafish larvae showed reasonable correlation between paracetamol clearance in zebrafish with that of higher vertebrates, including humans.<ref name=kantae2016/>