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==Safety and toxicity== {{Main|Health and safety hazards of nanomaterials| Toxicology of carbon nanomaterials}} In 2013, a comprehensive review on the toxicity of fullerene was published reviewing work beginning in the early 1990s to present and concluded that very little evidence gathered since the discovery of fullerenes indicate that {{chem|C|60}} is toxic.<ref name=lalwa2013/> The toxicity of these carbon [[nanoparticle]]s is not only dose- and time-dependent, but also depends on a number of other factors such as: * type (e.g.: {{chem|C|60}}, {{chem|C|70}}, M@{{chem|C|60}}, M@{{chem|C|82}}) * functional groups used to water-solubilize these nanoparticles (e.g.: OH, COOH) * method of administration (e.g.: intravenous, intraperitoneal) It was recommended to assess the pharmacology of every new fullerene- or metallofullerene-based complex individually as a different compound.
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