Editing Aspirin (section)

===Reye syndrome===
{{Main|Reye syndrome}}
Reye syndrome, a rare but severe illness characterized by acute [[encephalopathy]] and [[fatty liver]], can occur when children or adolescents are given aspirin for a fever or other illness or infection. From 1981 to 1997, 1207 cases of Reye syndrome in people younger than 18 were reported to the US [[Centers for Disease Control and Prevention]] (CDC). Of these, 93% reported being ill in the three weeks preceding the onset of Reye syndrome, most commonly with a [[Respiratory tract infection|respiratory infection]], [[chickenpox]], or [[diarrhea]]. Salicylates were detectable in 81.9% of children for whom test results were reported.<ref name=Belay>{{cite journal |vauthors = Belay ED, Bresee JS, Holman RC, Khan AS, Shahriari A, Schonberger LB |title = Reye's syndrome in the United States from 1981 through 1997 |journal = The New England Journal of Medicine |volume = 340 |issue = 18 |pages = 1377–82 |date = May 1999 |pmid = 10228187 |doi = 10.1056/NEJM199905063401801 |doi-access = free }}</ref> After the association between Reye syndrome and aspirin was reported, and safety measures to prevent it (including a [[Surgeon General of the United States|Surgeon General]]'s warning, and changes to the labeling of aspirin-containing drugs) were implemented, aspirin taken by children declined considerably in the United States, as did the number of reported cases of Reye syndrome; a similar decline was found in the United Kingdom after warnings against pediatric aspirin use were issued.<ref name=Belay/> The US [[Food and Drug Administration]] recommends aspirin (or aspirin-containing products) should not be given to anyone under the age of 12 who has a fever,<ref name="BMJ2002-Macdonald"/> and the UK [[National Health Service]] recommends children who are under 16 years of age should not take aspirin, unless it is on the advice of a doctor.<ref>{{cite web |url=https://www.nhs.uk/conditions/reyes-syndrome/|title= Reye's syndrome |publisher=National Health Service |work=Health A to Z|date= 14 September 2023|access-date=24 August 2024}}</ref>