Editing Antiandrogen (section)

==Society and culture==

===Etymology===
The term ''antiandrogen'' is generally used to refer specifically to AR antagonists, as described by Dorfman (1970):<ref name="pmid66176">{{cite journal | vauthors = Neumann F | title = Pharmacology and potential use of cyproterone acetate | journal = Hormone and Metabolic Research | volume = 9 | issue = 1 | pages = 1–13 | date = January 1977 | pmid = 66176 | doi = 10.1055/s-0028-1093574 | s2cid = 7224893 }}</ref><ref name="Dorfman1970">{{cite journal| vauthors = Dorfman RI |title=Biological Activity of Antiandrogens|journal=British Journal of Dermatology|volume=82|issue=s6|year=1970|pages=3|issn=0007-0963|doi=10.1111/j.1365-2133.1970.tb07998.x|s2cid=71393789}}</ref>

{{Blockquote|''Antiandrogens are substances which prevent androgens from expressing their activity at target sites. The inhibitory effect of these substances, therefore, should be differentiated from compounds which decrease the synthesis and/or release of hypothalamic (releasing) factors, from anterior pituitary hormones (gonadotropins, particularly luteinizing hormone) and from material which acts directly on the gonads to inhibit biosynthesis and/or secretion of androgens.''<ref name="pmid66176" /><ref name="Dorfman1970" />}}

However, in spite of the above, the term may also be used to describe ''functional'' antiandrogens like androgen synthesis inhibitors and antigonadotropins, including even estrogens and progestogens.<ref name="Brueggemeier2006" /><ref name="pmid11502457" /><ref name="GräfBrotherton1974">{{cite book| vauthors = Gräf KJ, Brotherton J, Neumann F |title=Androgens II and Antiandrogens / Androgene II und Antiandrogene|chapter=Clinical Uses of Antiandrogens |year=1974 |pages=485–542|publisher=Springer |doi=10.1007/978-3-642-80859-3_7|isbn=978-3-642-80861-6}}</ref> For example, the progestogen and hence antigonadotropin medroxyprogesterone acetate is sometimes described as a steroidal antiandrogen, even though it is not an antagonist of the AR.<ref name="Vogelzang2006">{{cite book| vauthors = Vogelzang N |title=Comprehensive Textbook of Genitourinary Oncology|url=https://books.google.com/books?id=WIsiGZnZ_mgC&pg=PA316 |year=2006 |publisher= Lippincott Williams & Wilkins|isbn=978-0-7817-4984-8|pages=316–}}</ref><ref name="GräfBrotherton1974" />