Editing Malaria (section)

===Resistance===
[[Drug resistance]] poses a growing problem in 21st-century malaria treatment.<ref name="Sinha-2014" /> In the 2000s (decade), malaria with partial resistance to artemisins emerged in Southeast Asia.<ref name="O'Brien-2011" /><ref name="Fairhurst-2012" /> Resistance is now common against all classes of antimalarial drugs apart from [[artemisinin]]s. Treatment of resistant strains became increasingly dependent on this class of drugs. The cost of artemisinins limits their use in the developing world.<ref name="White-2008" /> Malaria strains found on the Cambodia–Thailand border are resistant to combination therapies that include artemisinins, and may, therefore, be untreatable.<ref name="Wongsrichanalai-2008" /> Exposure of the parasite population to artemisinin monotherapies in subtherapeutic doses for over 30 years and the availability of substandard artemisinins likely drove the selection of the resistant phenotype.<ref name="Dondorp-2010" /> Resistance to artemisinin has been detected in Cambodia, Myanmar, Thailand, and Vietnam,<ref>{{cite journal|author=World Health Organization |title=Q&A on artemisinin resistance |journal=WHO Malaria Publications |year=2013 |url=https://www.who.int/malaria/media/artemisinin_resistance_qa/en/index.html |url-status=dead |archive-url=https://web.archive.org/web/20160720075407/http://www.who.int/malaria/media/artemisinin_resistance_qa/en/index.html |archive-date=2016-07-20 }}</ref> and there has been emerging resistance in Laos.<ref name="Briggs-2014">{{cite news|vauthors=Briggs H|date=2014-07-30|title=Call for 'radical action' on drug-resistant malaria|language=en-GB|work=BBC News|url=https://www.bbc.com/news/health-28569966|access-date=2023-02-23|archive-date=2023-02-23|archive-url=https://web.archive.org/web/20230223035718/https://www.bbc.com/news/health-28569966|url-status=live}}</ref><ref name="Ashley-2014" /> Resistance to the combination of artemisinin and piperaquine was first detected in 2013 in Cambodia, and by 2019 had spread across Cambodia and into [[Laos]], [[Thailand]] and [[Vietnam]] (with up to 80 percent of malaria parasites resistant in some regions).<ref>{{cite news|url=https://www.bbc.com/news/health-49017699|title=Resistant malaria spreading in South East Asia|vauthors=Gallagher J|date=2019-07-23|access-date=2019-07-25|language=en-GB|archive-date=2019-07-24|archive-url=https://web.archive.org/web/20190724221856/https://www.bbc.com/news/health-49017699|url-status=live}}</ref>

There is insufficient evidence in unit packaged antimalarial drugs in preventing treatment failures of malaria infection. However, if supported by training of healthcare providers and patient information, there is improvement in compliance of those receiving treatment.<ref>{{cite journal | vauthors = Orton L, Barnish G | title = Unit-dose packaged drugs for treating malaria | journal = The Cochrane Database of Systematic Reviews | volume = 2005 | issue = 2 | pages = CD004614 | date = April 2005 | pmid = 15846723 | pmc = 6532754 | doi = 10.1002/14651858.CD004614.pub2 | collaboration = Cochrane Infectious Diseases Group }}</ref>