Editing Zebrafish (section)

===Drug screens===
Drug screens in zebrafish can be used to identify novel classes of compounds with biological effects, or to repurpose existing drugs for novel uses; an example of the latter would be a screen which found that a commonly used statin ([[rosuvastatin]]) can suppress the growth of [[prostate cancer]].<ref>{{cite journal |vauthors=Rennekamp AJ, Peterson RT |title=15 years of zebrafish chemical screening |journal=Current Opinion in Chemical Biology |volume=24 |pages=58–70 |date=February 2015 |pmid=25461724 |pmc=4339096 |doi=10.1016/j.cbpa.2014.10.025}}</ref> To date, 65 small-molecule screens have been carried out and at least one has led to clinical trials.<ref name=":0">{{cite journal |vauthors=MacRae CA, Peterson RT |title=Zebrafish as tools for drug discovery |journal=[[Nature Reviews Drug Discovery]] |volume=14 |issue=10 |pages=721–731 |date=October 2015 |pmid=26361349 |doi=10.1038/nrd4627 |s2cid=1979653}}</ref> Within these screens, many technical challenges remain to be resolved, including differing rates of drug absorption resulting in levels of internal exposure that cannot be extrapolated from the water concentration, and high levels of natural variation between individual animals.<ref name=":0" />