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==Precautions== Titanium is non-toxic even in large doses and does not play any natural role inside the [[human body]].<ref name="Emsley2001p451" /> An estimated quantity of 0.8 milligrams of titanium is ingested by humans each day, but most passes through without being absorbed in the tissues.<ref name="Emsley2001p451" /> It does, however, sometimes [[bioaccumulation|bio-accumulate]] in tissues that contain [[silica]]. One study indicates a possible connection between titanium and [[yellow nail syndrome]].<ref>{{cite journal |last1=Berglund |first1=Fredrik |author2=Carlmark, Bjorn |title=Titanium, Sinusitis, and the Yellow Nail Syndrome |journal=Biological Trace Element Research |date=October 2011 |pmc=3176400 |volume=143 |issue=1 |pages=1–7 |doi=10.1007/s12011-010-8828-5 |pmid=20809268|bibcode=2011BTER..143....1B }}</ref> As a powder or in the form of metal shavings, titanium metal poses a significant fire hazard and, when heated in [[air]], an explosion hazard.<ref>{{cite book |last=Cotell |first=Catherine Mary |author2=Sprague, J.A. |author3=Smidt, F.A. |title=ASM Handbook: Surface Engineering |publisher=[[ASM International (society)|ASM International]] |year=1994 |edition=10th |page=836 |isbn=978-0-87170-384-2 |url=https://books.google.com/books?id=RGtsPjqUwy0C}}</ref> Water and [[carbon dioxide]] are ineffective for extinguishing a titanium fire; [[fire classes|Class D]] dry powder agents must be used instead.<ref name="HistoryAndUse" /> When used in the production or handling of chlorine, titanium should not be exposed to dry chlorine gas because it may result in a titanium–chlorine fire.<ref>{{cite book |author=Compressed Gas Association |title=Handbook of compressed gases |publisher=Springer |year=1999 |edition=4th |page=323 |isbn=978-0-412-78230-5 |url=https://books.google.com/books?id=WSLULtCG9JgC}}</ref> Titanium can catch fire when a fresh, non-oxidized surface comes in contact with [[liquid oxygen]].<ref>{{cite book |last=Solomon |first=Robert E. |others=National Fire Prevention Association |title=Fire and Life Safety Inspection Manual |publisher=Jones & Bartlett Publishers |year=2002 |edition=8th |page=45 |isbn=978-0-87765-472-8 |url=https://books.google.com/books?id=2fHsoobsCNwC}}</ref>
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