Editing Cardiology (section)

== Trials ==
Cardiology is known for [[randomized controlled trial]]s that guide clinical treatment of cardiac diseases. While dozens are published every year, there are landmark trials that shift treatment significantly. Trials often have an acronym of the trial name, and this acronym is used to reference the trial and its results. Some of these landmark trials include:

* V-HeFT (1986) — use of vasodilators (hydralazine and isosorbide dinitrate) in heart failure
* ISIS-2 (1988) — use of aspirin in myocardial infarction
* CASE I (1991) — use of [[antiarrhythmic agent]]s after a heart attack increases mortality
* SOLVD (1991) — use of [[ACE inhibitor]]s in heart failure
* 4S (1994) — [[statin]]s reduce risk of heart disease
* CURE (1991) — use of [[dual antiplatelet therapy]] in [[NSTEMI]]
* MIRACLE (2002) — use of [[cardiac resynchronization therapy]] in heart failure
* SCD-HeFT (2005) — the use of [[implantable cardioverter-defibrillator]] in heart failure
* RELY (2009), ROCKET-AF (2011), ARISTOTLE (2011) — use of [[DOAC]]s in [[atrial fibrillation]] instead of warfarin
* PARADIGM-HF (2014) — use of angiotensin-neprilysin inhibitor in heart failure
* ISCHEMIA (2020) — medical therapy is as good as [[coronary stent]]s in stable heart disease
* EMPEROR-Preserved (2021) — SGLT2 receptors in heart failure