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=== Pre–industrial revolution === [[Georg Ernst Stahl]] mentioned ''carbonarii halitus'' in 1697 in reference to toxic vapors thought to be carbon monoxide. [[Friedrich Hoffmann]] conducted the first modern scientific investigation into carbon monoxide poisoning from coal in 1716. [[Herman Boerhaave]] conducted the first scientific experiments on the effect of carbon monoxide (coal fumes) on animals in the 1730s.<ref name="Hopper2021" /> [[Joseph Priestley]] is considered to have first synthesized carbon monoxide in 1772. [[Carl Wilhelm Scheele]] similarly isolated carbon monoxide from charcoal in 1773 and thought it could be the carbonic entity making fumes toxic. [[Torbern Bergman]] isolated carbon monoxide from [[oxalic acid]] in 1775. Later in 1776, the French chemist {{ill|de Lassone|fr|Joseph-Marie-François de Lassone}} produced CO by heating [[zinc oxide]] with [[Coke (fuel)|coke]], but mistakenly concluded that the gaseous product was [[hydrogen]], as it burned with a blue flame. In the presence of oxygen, including atmospheric concentrations, carbon monoxide burns with a blue flame, producing carbon dioxide. [[Antoine Lavoisier]] conducted similar inconclusive experiments to Lassone in 1777. The gas was identified as a compound containing [[carbon]] and [[oxygen]] by [[William Cruickshank (chemist)|William Cruickshank]] in 1800.<ref name="Hopper2021" /><ref>{{Cite book |last=Stromeyer |first=Friedrich |url=https://books.google.com/books?id=MLg5AAAAcAAJ&q=hydrocarbonate+cruickshank&pg=PA1 |title=Grundriß der theoretischen Chemie: zum Behuf seiner Vorlesungen entworfen |date=1808 |publisher=Röwer |pages=1–18 |language=de}}</ref> [[Thomas Beddoes]] and [[James Watt]] recognized carbon monoxide (as [[Hydrocarbonate (gas)|hydrocarbonate]]) to brighten venous blood in 1793. Watt suggested coal fumes could act as an antidote to the oxygen in blood, and Beddoes and Watt likewise suggested hydrocarbonate has a greater affinity for animal fiber than oxygen in 1796. In 1854, [[Adrien Chenot]] similarly suggested carbon monoxide to remove the oxygen from blood and then be oxidized by the body to carbon dioxide.<ref name="Hopper2021" /> The mechanism for carbon monoxide poisoning is widely credited to [[Claude Bernard]] whose memoirs beginning in 1846 and published in 1857 phrased, "prevents arterials blood from becoming venous". [[Felix Hoppe-Seyler]] independently published similar conclusions in the following year.<ref name="Hopper2021" />
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