Editing Macrophage (section)

=== HIV infection ===
Macrophages also play a role in [[human Immunodeficiency Virus|human immunodeficiency virus]] (HIV) infection. Like [[T cells]], macrophages can be infected with HIV, and even become a reservoir of ongoing virus replication throughout the body. HIV can enter the macrophage through binding of gp120 to CD4 and second membrane receptor, CCR5 (a chemokine receptor). Both circulating monocytes and macrophages serve as a reservoir for the virus.<ref>{{cite journal| vauthors = Bol SM, Cobos-Jiménez V, Kootstra NA, van't Wout AB |date=February 2011|title=Macrophage |journal=Future Virology|volume=6|issue=2|pages=187–208|doi=10.2217/fvl.10.93}}</ref> Macrophages are better able to resist infection by HIV-1 than CD4+ T cells, although susceptibility to HIV infection differs among macrophage subtypes.<ref>{{cite journal | vauthors = Koppensteiner H, Brack-Werner R, Schindler M | title = Macrophages and their relevance in Human Immunodeficiency Virus Type I infection | journal = Retrovirology | volume = 9 | issue = 1 | pages = 82 | date = October 2012 | pmid = 23035819 | pmc = 3484033 | doi = 10.1186/1742-4690-9-82 | doi-access = free }}</ref>