Editing Enzyme (section)

====Subcellular distribution====
Enzymes can be compartmentalized, with different metabolic pathways occurring in different [[cellular compartment]]s. For example, [[fatty acid]]s are synthesized by one set of enzymes in the [[cytosol]], [[endoplasmic reticulum]] and [[golgi apparatus|Golgi]] and used by a different set of enzymes as a source of energy in the [[mitochondrion]], through [[β-oxidation]].<ref>{{cite journal | vauthors = Faergeman NJ, Knudsen J | title = Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling | journal = The Biochemical Journal | volume = 323 | issue = Pt 1 | pages = 1–12 | date = April 1997 | pmid = 9173866 | pmc = 1218279 | doi = 10.1042/bj3230001 }}</ref> In addition, [[protein targeting|trafficking]] of the enzyme to different compartments may change the degree of [[protonation]] (e.g., the neutral [[cytoplasm]] and the acidic [[lysosome]]) or oxidative state (e.g., oxidizing [[periplasm]] or reducing [[cytoplasm]]) which in turn affects enzyme activity.<ref name = "Suzuki_2015_4">{{cite book | author = Suzuki H | title = How Enzymes Work: From Structure to Function | publisher = CRC Press | location = Boca Raton, FL | year = 2015 | isbn = 978-981-4463-92-8 | chapter = Chapter 4: Effect of pH, Temperature, and High Pressure on Enzymatic Activity | pages = 53–74 }}</ref> In contrast to partitioning into membrane bound organelles, enzyme subcellular localisation may also be altered through polymerisation of enzymes into macromolecular cytoplasmic filaments.<ref>{{cite journal | vauthors = Noree C, Sato BK, Broyer RM, Wilhelm JE | title = Identification of novel filament-forming proteins in Saccharomyces cerevisiae and Drosophila melanogaster | journal = The Journal of Cell Biology | volume = 190 | issue = 4 | pages = 541–551 | date = August 2010 | pmid = 20713603 | pmc = 2928026 | doi = 10.1083/jcb.201003001 }}</ref><ref>{{cite journal | vauthors = Aughey GN, Liu JL | title = Metabolic regulation via enzyme filamentation | journal = Critical Reviews in Biochemistry and Molecular Biology | volume = 51 | issue = 4 | pages = 282–293 | date = 2015 | pmid = 27098510 | pmc = 4915340 | doi = 10.3109/10409238.2016.1172555 }}</ref>