Editing Crohn's disease (section)

=== Immunodeficiency theory ===
{{Update section|date=May 2024|reason=All current sources are from 2010}}
A substantial body of data has emerged in recent years to suggest that the primary defect in Crohn's disease is actually one of relative [[immunodeficiency]].<ref name="Marks 20–31">{{cite journal | vauthors = Marks DJ, Rahman FZ, Sewell GW, Segal AW | title = Crohn's disease: an immune deficiency state | journal = Clinical Reviews in Allergy & Immunology | volume = 38 | issue = 1 | pages = 20–31 | date = February 2010 | pmid = 19437144 | pmc = 4568313 | doi = 10.1007/s12016-009-8133-2 }}</ref> This view has been bolstered recently by novel immunological and clinical studies that have confirmed gross aberrations in this early response, consistent with subsequent genetic studies that have highlighted molecules important for [[Innate immune system|innate immune function]]. The suggestion therefore is that Crohn's [[pathogenesis]] actually results from partial immunodeficiency, a theory that coincides with the frequent recognition of a virtually identical, non-infectious inflammatory bowel disease arising in people with [[congenital]] [[Monogenic (genetics)|monogenic]] disorders impairing [[phagocyte]] function.<ref name="Marks 20–31" />