Editing Antidepressant (section)

===Serotonin–norepinephrine reuptake inhibitors===
[[File:Venlafaxine-3D-balls.png|thumb|right|alt=chemical structure of the SNRI drug venlafaxine|The chemical structure of [[venlafaxine]] (Effexor), an [[Serotonin–norepinephrine reuptake inhibitor|SNRI]]]]

[[Serotonin–norepinephrine reuptake inhibitor]]s (SNRIs) are potent inhibitors of the [[reuptake]] of [[serotonin]] and [[norepinephrine]]. These [[neurotransmitter]]s are known to play an important role in mood. SNRIs can be contrasted with the more widely used [[selective serotonin reuptake inhibitor]]s (SSRIs), which act mostly upon serotonin alone.

The human [[serotonin transporter]] (SERT) and [[norepinephrine transporter]] (NET) are [[membrane protein]]s that are responsible for the reuptake of serotonin and norepinephrine. Balanced dual inhibition of [[monoamine]] reuptake may offer advantages over other antidepressants drugs by treating a wider range of symptoms.<ref name="pmid19740668">{{cite journal|vauthors=Cashman JR, Ghirmai S|title=Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents for depression|journal=Bioorganic & Medicinal Chemistry|volume=17|issue=19|pages=6890–6897|date=October 2009|pmid=19740668|doi=10.1016/j.bmc.2009.08.025}}</ref>

SNRIs are sometimes also used to treat [[anxiety disorder]]s, [[obsessive–compulsive disorder]] (OCD), [[attention deficit hyperactivity disorder]] (ADHD), chronic [[neuropathic pain]], and [[fibromyalgia syndrome]] (FMS), and for the relief of [[menopause|menopausal]] symptoms.