Editing MicroRNA (section)

===Hemostasis===
miRNAs also play crucial roles in the regulation of complex enzymatic cascades including the [[Hemostasis|hemostatic blood coagulation system]].<ref name="pmid25400249">{{cite journal | vauthors = Teruel-Montoya R, Rosendaal FR, Martínez C | title = MicroRNAs in hemostasis | journal = Journal of Thrombosis and Haemostasis | volume = 13 | issue = 2 | pages = 170–181 | date = February 2015 | pmid = 25400249 | doi = 10.1111/jth.12788 | doi-access = free }}</ref> Large scale studies of functional miRNA targeting have recently uncovered rationale therapeutic targets in the hemostatic system.<ref name="pmid30207063">{{cite journal | vauthors = Nourse J, Braun J, Lackner K, Hüttelmaier S, Danckwardt S | title = Large-scale identification of functional microRNA targeting reveals cooperative regulation of the hemostatic system | journal = Journal of Thrombosis and Haemostasis | volume = 16 | issue = 11 | pages = 2233–2245 | date = November 2018 | pmid = 30207063 | doi = 10.1111/jth.14290 | doi-access = free }}</ref><ref name="pmid32898547">{{cite journal | vauthors = Nourse J, Danckwardt S | title = A novel rationale for targeting FXI: Insights from the hemostatic microRNA targetome for emerging anticoagulant strategies | journal = Pharmacology & Therapeutics | volume = 218 | pages = 107676 | date = February 2021 | pmid = 32898547 | doi = 10.1016/j.pharmthera.2020.107676 | doi-access = free }}</ref> They have been directly linked to [[Calcium metabolism|Calcium homeostasis]] in the [[endoplasmic reticulum]], which is critical in cell differentiation in early development.<ref>{{cite journal | vauthors = Berardi E, Pues M, Thorrez L, Sampaolesi M | title = miRNAs in ESC differentiation | journal = American Journal of Physiology. Heart and Circulatory Physiology | volume = 303 | issue = 8 | pages = H931–H939 | date = October 2012 | doi = 10.1152/ajpheart.00338.2012 | pmid = 22886416 | s2cid = 6402014 }}</ref>