Editing Macrophage (section)

=== Heart disease ===
Macrophages are the predominant cells involved in creating the progressive plaque lesions of [[atherosclerosis]].<ref>{{cite journal | vauthors = Lucas AD, Greaves DR | title = Atherosclerosis: role of chemokines and macrophages | journal = Expert Reviews in Molecular Medicine | volume = 3 | issue = 25 | pages = 1–18 | date = November 2001 | pmid = 14585150 | doi = 10.1017/S1462399401003696 | s2cid = 8952545 }}</ref>

Focal recruitment of macrophages occurs after the onset of acute [[myocardial infarction]]. These macrophages function to remove debris, apoptotic cells and to prepare for [[Regeneration (biology)|tissue regeneration]].<ref>{{cite journal | vauthors = Frantz S, Nahrendorf M | title = Cardiac macrophages and their role in ischaemic heart disease | journal = Cardiovascular Research | volume = 102 | issue = 2 | pages = 240–248 | date = May 2014 | pmid = 24501331 | pmc = 3989449 | doi = 10.1093/cvr/cvu025 }}</ref> Macrophages protect against ischemia-induced ventricular tachycardia in hypokalemic mice.<ref>{{cite journal | vauthors = Grune J, Lewis AJ, Yamazoe M, Hulsmans M, Rohde D, Xiao L, Zhang S, Ott C, Calcagno DM, Zhou Y, Timm K, Shanmuganathan M, Pulous FE, Schloss MJ, Foy BH, Capen D, Vinegoni C, Wojtkiewicz GR, Iwamoto Y, Grune T, Brown D, Higgins J, Ferreira VM, Herring N, Channon KM, Neubauer S, Sosnovik DE, Milan DJ, Swirski FK, King KR, Aguirre AD, Ellinor PT, Nahrendorf M | title = Neutrophils incite and macrophages avert electrical storm after myocardial infarction | journal = Nature Cardiovascular Research | volume = 1 | issue = 7 | pages = 649–664 | date = July 2022 | pmid = 36034743 | pmc = 9410341 | doi = 10.1038/s44161-022-00094-w | s2cid = 250475623 }}</ref>